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University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg

4 ARTICLES PUBLISHED IN JoVE

Medicine

Blood Circuit Reconstruction in an Abdominal Mouse Heart Transplantation Model

Decheng Yin^*1,2, Jian Fu^*1,3, Ida Allabauer¹, Oliver Witzke⁴, Song Rong⁵, André Hoerning¹

¹Department of Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, ²Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital, ³The Key Laboratory of Hainan Trauma and Disaster Rescue, The first affiliated Hospital of Hainan Medical University, ⁴Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, ⁵Department of Nephrology, Hannover Medical School

A novel technique for blood circuit reconstruction in a heterotopic abdominal mouse heart transplantation model is demonstrated.

Immunology and Infection

A Modified Surgical Technique for Kidney Transplantation in Mice

Decheng Yin^*1,2, Jian Fu^*1,3, Rongjun Chen⁴, Nelli Shushakova⁵, Ida Allabauer¹, Xin-Yi Wei¹, Mario Schiffer⁶, Diana Dudziak⁷, Song Rong^*5, André Hoerning^*1

¹Department of Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, ²Department of Pediatric Surgery, Chengdu Women’s and Children's Central Hospital, ³The Key Laboratory of Hainan Trauma and Disaster Rescue, The first affiliated Hospital of Hainan Medical University, ⁴Department of Department of Pediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, ⁵Department of Nephrology, Hannover Medical School, ⁶Department of Nephrology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, ⁷Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg

This protocol presents a new surgical technique of mouse kidney transplantation focusing on a modified arterial anastomosis strategy. A vascular suture technique including a simple and safer ureter-bladder anastomosis method is also presented. These modifications shorten the operation time and improve the success rate of the mouse kidney transplantation procedure.

Engineering

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators

Jiangao Zhao^1,2, Deming Zhu^2,3, Yuxuan Ma^2,3, Yongling Fu^2,3, Jian Fu^2,3

¹Research Institute for Frontier Science, Beihang University, ²School of Mechanical Engineering and Automation, Beihang University, ³Laboratory of Aerospace Servo Actuation and Transmission, Beihang University

We built a simulation model to evaluate pump flow characteristics and performance of the single-shaft coaxial motor-pump assembly in electrohydrostatic actuators and investigate the overall efficiency in a wide set of working conditions of the motor-pump assembly experimentally.

JoVE Core

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Xu Han¹, Peng Zhang², Tatiana Minav³, Yongling Fu¹, Jian Fu¹

¹School of Mechanical Engineering and Automation, Beihang University, ²Beijing Institute of Precision Mechatronics and Controls, ³Innovative Hydraulics and Automation, Tampere University

A simulation model specifically supporting the preliminary design of an electro-variable displacement pump (EVDP) is developed and partially verified by experiments. The control performance, life, reliability, etc., can all be evaluated using the proposed model, which covers the main performance requirements under the EVDP preliminary design task.