Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
On the protective side:
The interplay of these factors either heightens acid-pepsin levels or weakens the mucosal barrier's resistance. Damaged mucosa struggles to produce sufficient mucus as a defense, leading to inflammation, harm, and mucosal erosion.
Do Capítulo 10:
Now Playing
Gastric and Duodenal Disorders
280 Visualizações
Gastric and Duodenal Disorders
276 Visualizações
Gastric and Duodenal Disorders
250 Visualizações
Gastric and Duodenal Disorders
157 Visualizações
Gastric and Duodenal Disorders
133 Visualizações
Gastric and Duodenal Disorders
88 Visualizações
Gastric and Duodenal Disorders
72 Visualizações
Gastric and Duodenal Disorders
228 Visualizações
Copyright © 2025 MyJoVE Corporation. Todos os direitos reservados