Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
On the protective side:
The interplay of these factors either heightens acid-pepsin levels or weakens the mucosal barrier's resistance. Damaged mucosa struggles to produce sufficient mucus as a defense, leading to inflammation, harm, and mucosal erosion.
Из главы 10:
Now Playing
Gastric and Duodenal Disorders
275 Просмотры
Gastric and Duodenal Disorders
269 Просмотры
Gastric and Duodenal Disorders
242 Просмотры
Gastric and Duodenal Disorders
153 Просмотры
Gastric and Duodenal Disorders
133 Просмотры
Gastric and Duodenal Disorders
88 Просмотры
Gastric and Duodenal Disorders
72 Просмотры
Gastric and Duodenal Disorders
228 Просмотры
Авторские права © 2025 MyJoVE Corporation. Все права защищены