Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
On the protective side:
The interplay of these factors either heightens acid-pepsin levels or weakens the mucosal barrier's resistance. Damaged mucosa struggles to produce sufficient mucus as a defense, leading to inflammation, harm, and mucosal erosion.
From Chapter 10:
Now Playing
Gastric and Duodenal Disorders
115 Views
Gastric and Duodenal Disorders
187 Views
Gastric and Duodenal Disorders
149 Views
Gastric and Duodenal Disorders
85 Views
Gastric and Duodenal Disorders
75 Views
Gastric and Duodenal Disorders
59 Views
Gastric and Duodenal Disorders
40 Views
Gastric and Duodenal Disorders
125 Views
Copyright © 2025 MyJoVE Corporation. All rights reserved