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Chemistry

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Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

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10:12 min

April 4th, 2014

April 4th, 2014

12,843 Views

0:05

Title

1:41

Preparation of Titanium(IV) tert-butoxide/Triethylchlorosilane Solution and Pinacol-reaction of Tetraphenyl-1,2-ethanediol with 2-Ethylbutyraldehyde

4:37

Pinacol-reaction of Tetraphenyl-1,2-ethanediol with Diethyl Ketone

7:12

Results: Synthesis of 1,2-Unsymmetrical Diols via Retropinacol/Cross-pinacol Coupling

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Conclusion

A novel account for the synthesis of unsymmetrical 1,2-diols based on a retropinacol/cross-pinacol coupling mechanism is described. Due to the catalytic execution of this reaction a considerable improvement compared to conventional cross-pinacol couplings is achieved.

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