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JoVE Journal

Medicine

This content is Open Access.

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

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12:01 min

June 14th, 2018

June 14th, 2018

12,319 Views

0:05

Title

2:20

CT Acquisition

3:34

PET Acquistion

5:48

Dynamic PET Image Analysis

10:23

Results: [11C]DPA-713 is Effective in Quantifying Neuroinflammation in the dMCAO Mouse Model of Stroke

11:00

Conclusion

Transcrição

Positron Emission Tomography (PET) imaging of translocator protein 18 kDa (TSPO) provides a non-invasive means to visualize the dynamic role of neuroinflammation in the development and progression of brain diseases. This protocol describes TSPO-PET and ex vivo autoradiography to detect neuroinflammation in a mouse model of ischemic stroke.

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