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JoVE Journal

Bioengineering

This content is Open Access.

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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09:39 min

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February 7th, 2021

February 7th, 2021

•
7,222 Views

0:04

Introduction

0:49

Nanoparticle (NP) Synthesis

2:10

Hydrogel Formulation and Rheological Property Measurement

3:27

In Vitro Drug Release Characterization

4:35

Thermal Stability of Gel-Encapsulated Insulin Characterization

5:19

Cell Viability Assessment

6:08

Cell Settling Assessment

7:15

Results: Representative Polymer Nanoparticle (PNP) Hydrogel Release Kinetics, Cargo Stability, and Cell Viability

9:00

Conclusion

Transcrição

This protocol describes the synthesis and formulation of injectable, supramolecular polymer-nanoparticle (PNP) hydrogel biomaterials. Applications of these materials for drug delivery, biopharmaceutical stabilization, and cell encapsulation and delivery are demonstrated.

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