Roland K.O. Sigel

Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif.

Acid-base and metal-ion binding properties of the RNA dinucleotide uridylyl-(5'-->3')-[5']uridylate (pUpU3-).

Acid-base properties of the nucleic-acid model 2'-deoxyguanylyl(5'-->3')-2'-deoxy-5'-guanylate, d(pGpG)3-, and of related guanine derivatives.

Metal-ion-coordinating properties of the dinucleotide 2'-deoxyguanylyl(5'-->3')-2'-deoxy-5'-guanylate (d(pGpG)3-): isomeric equilibria including macrochelated complexes relevant for nucleic acids.

Solution structure of domain 6 from a self-splicing group II intron ribozyme: a Mg(2+) binding site is located close to the stacked branch adenosine.

Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry.

Binding interaction of [Re(H2O)3(CO)3]+ with the DNA fragment d(CpGpG).

Determination of the intrinsic affinities of multiple site-specific Mg(2+) ions coordinated to domain 6 of a group II intron ribozyme.

Discrimination in metal-ion binding to RNA dinucleotides with a non-bridging oxygen or sulfur in the phosphate diester link.

Using in vitro transcription to construct scaffolds for one-dimensional arrays of mercuric ions.

The corrin moiety of coenzyme B12 is the determinant for switching the btuB riboswitch of E. coli.

Divalent metal ions tune the self-splicing reaction of the yeast mitochondrial group II intron Sc.ai5gamma.

Comparison of the acid-base properties of ribose and 2'-deoxyribose nucleotides.

Single-molecule studies of group II intron ribozymes.

Effect of the ribose versus 2'-deoxyribose residue on the metal ion-binding properties of purine nucleotides.

Divalent metal ions promote the formation of the 5'-splice site recognition complex in a self-splicing group II intron.

Ca2+ induces the formation of two distinct subpopulations of group II intron molecules.

Controlling ribozyme activity by metal ions.

Metal ion-N7 coordination in a ribozyme branch domain by NMR.

A stability concept for metal ion coordination to single-stranded nucleic acids and affinities of individual sites.

The change of corrin-amides to carboxylates leads to altered structures of the B12-responding btuB riboswitch.

Solution structure of a DNA double helix with consecutive metal-mediated base pairs.

Shaping RNA structures with metal ions and metal ion complexes.

Stability and structure of mixed-ligand metal ion complexes that contain Ni2+, Cu2+, or Zn2+, and Histamine, as well as adenosine 5'-triphosphate (ATP4-) or uridine 5'-triphosphate (UTP(4-): an intricate network of equilibria.

Probing the metal-ion-binding strength of the hydroxyl group.

MINAS--a database of Metal Ions in Nucleic AcidS.

Characterization of metal ion-nucleic acid interactions in solution.

Single molecule FRET characterization of large ribozyme folding.

Metal ion-RNA interactions studied via multinuclear NMR.

Unusually high-affinity Mg(2+) binding at the AU-rich sequence within the antiterminator hairpin of a Mg(2+) riboswitch.

NMR spectroscopy in bioinorganic chemistry.

The structural stabilization of the κ three-way junction by Mg(II) represents the first step in the folding of a group II intron.

Helicase-mediated changes in RNA structure at the single-molecule level.

Complex formation of cadmium with sugar residues, nucleobases, phosphates, nucleotides, and nucleic acids.

Intrinsic acid-base properties of a hexa-2'-deoxynucleoside pentaphosphate, d(ApGpGpCpCpT): neighboring effects and isomeric equilibria.

Distance-dependent duplex DNA destabilization proximal to G-quadruplex/i-motif sequences.

Kinetic subpopulations detected by single-molecule spectroscopy: fundamental property of functional nucleic acids or experimental artefact?

Structure and conformational dynamics of the domain 5 RNA hairpin of a bacterial group II intron revealed by solution nuclear magnetic resonance and molecular dynamics simulations.

Diversity of cobalamin riboswitches in the corrinoid-producing organohalide respirer Desulfitobacterium hafniense.

Monitoring global structural changes and specific metal-ion-binding sites in RNA by in-line probing and Tb(III) cleavage.

Mg(2+)-induced conformational changes in the btuB riboswitch from E. coli.

BOBA FRET: bootstrap-based analysis of single-molecule FRET data.

NMR structure of the 5' splice site in the group IIB intron Sc.ai5γ--conformational requirements for exon-intron recognition.

Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts.

Solution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domain.

Synthesis, physico-chemical properties and biological analysis of newly obtained copper(II) complexes with pyrazole derivatives.

The role of Mg(II) in DNA cleavage site recognition in group II intron ribozymes: solution structure and metal ion binding sites of the RNA-DNA complex.

The AdoCbl-riboswitch interaction investigated by in-line probing and surface plasmon resonance spectroscopy (SPR).

Cation-induced kinetic heterogeneity of the intron-exon recognition in single group II introns.

Strategy for Internal Labeling of Large RNAs with Minimal Perturbation by Using Fluorescent PNA.

Explicit analytic equations for multimolecular thermal melting curves.

Protonation-Dependent Base Flipping at Neutral pH in the Catalytic Triad of a Self-Splicing Bacterial Group II Intron.

Studying metal ion binding properties of a three-way junction RNA by heteronuclear NMR.

Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme.

The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations.

Sequence-Specific Post-Synthetic Oligonucleotide Labeling for Single-Molecule Fluorescence Applications.

Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes.

An atomistic view on carbocyanine photophysics in the realm of RNA.

Influence of pH and Mg(ii) on the catalytic core domain 5 of a bacterial group II intron.

Tb-Cleavage Assays Reveal Specific Mg Binding Sites Necessary to Pre-fold the Riboswitch for AdoCbl Binding.

Site-specific dual-color labeling of long RNAs for single-molecule spectroscopy.

Specific phosphorothioate substitution within domain 6 of a group II intron ribozyme leads to changes in local structure and metal ion binding.

Celebrating Helmut Sigel.

Simulations of camera-based single-molecule fluorescence experiments.

Optimal molecular crowding accelerates group II intron folding and maximizes catalysis.

The Bioinorganic Periodic Table.

NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance.

Stick, Flick, Click: DNA-guided Fluorescent Labeling of Long RNA for Single-molecule FRET.

Concerted dynamics of metallo-base pairs in an A/B-form helical transition.

Site-Specific Dual-Color Labeling of Long RNAs.

Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts.

Encapsulation of Fluorescently Labeled RNAs into Surface-Tethered Vesicles for Single-Molecule FRET Studies in TIRF Microscopy.

Screening for potential interaction partners with surface plasmon resonance imaging coupled to MALDI mass spectrometry.

Puf6 primes 60S pre-ribosome nuclear export at low temperature.

FRETraj: integrating single-molecule spectroscopy with molecular dynamics.

Single-Molecule Kinetic Studies of Nucleic Acids by Förster Resonance Energy Transfer.

Chemical Dual End-Labeling of Large Ribozymes.

Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations.

Magnesium(II)-ATP Complexes in 1-Ethyl-3-Methylimidazolium Acetate Solutions Characterized by Mg β-Radiation-Detected NMR Spectroscopy.

A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories.

The structural features of the ligand-free moaA riboswitch and its ion-dependent folding.

Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks.

Group II Introns: Highly Structured yet Dynamic.

Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages.

From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes.

Reply to: On the statistical foundation of a recent single molecule FRET benchmark.

FRET-guided modeling of nucleic acids.

Corrin Ring Modifications Reveal the Chemical and Spatial Requirements for the B-btuB Riboswitch Interaction.