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A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration

645 Views

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05:07 min

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August 2nd, 2024

DOI :

10.3791/66674-v

August 2nd, 2024

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Jinting Ge*¹, Chengxin Weng*¹, Xiaoling Zhang², Jichun Zhao¹, Hua Zhang², Ding Yuan¹, Tiehao Wang¹

¹Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, ²Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University

Summary

This manuscript presents a protocol for establishing a mouse abdominal aortic aneurysm model using calcium chloride and elastase, combining the advantages of previous modeling methods. This model can be utilized to investigate the pathophysiological mechanisms underlying abdominal aortic aneurysms.

Explore More Videos

Mouse Abdominal Aortic Aneurysm

Calcium Chloride

Porcine Pancreatic Elastase

Pathophysiological Mechanism

Periadventitial Infiltration

Aneurysm Dilation

Therapeutic Approaches

AAA Formation Rate

Ultrasound Experiments

Histological Experiments

Chapters in this video

0:00

Introduction

1:10

Surgical Induction and Evaluation of Abdominal Aortic Aneurysm in Mice

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