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Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

DOI :

10.3791/60105-v

August 24th, 2019

August 24th, 2019

7,319 Views

1Department of Surgery, University of Virginia School of Medicine, 2Department of Surgery, Ochsner Medical Center, 3Department of Surgery, University of Florida, 4The Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine

We describe a surgical protocol to consistently induce robust descending thoracic aortic aneurysms in mice. The procedure involves left thoracotomy, thoracic aorta exposure, and placement of a sponge soaked in porcine pancreatic elastase on the aortic wall.

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Murine Surgical Model

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