Chapter 23
Drugs for Chronic Bowel Disorders
Chronic Bowel Disorders: Introduction
Chronic bowel disorders are long-term medical conditions affecting the digestive tract, including disorders such as irritable bowel syndrome or IBS and ...
Drugs for Treatment of Diarrhea-Predominant IBS
Diarrhea-predominant irritable bowel syndrome or IBS-D, is characterized by chronic abdominal pain and diarrhea.
Effective IBS-D management involves ...
Drugs for Treatment of Constipation-Predominant IBS
Irritable bowel syndrome with constipation or IBS-C, is a recurring digestive disorder characterized by abdominal pain and infrequent bowel movements.
...
Drugs for Treatment of Ulcerative Colitis in IBD
Ulcerative colitis is characterized by mucosal inflammation of the colon.
The first-line agent, 5-aminosalicylic acid or 5-ASA, inhibits leukotriene and ...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder characterized by discontinuous chronic inflammation of the GI tract.
Treatment strategies encompass ...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor necrosis factor, or TNF, a proinflammatory cytokine, exists in soluble or membrane-bound form.
TNF-receptor interaction triggers NF-κB, T-cell ...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, like prednisone, are potent anti-inflammatory agents that induce effective remission in Crohn's patients.
These bind and activate ...
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