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Clinical assessment scales are notsensitive enough to cognitive dysfunction in high-functioning stroke patients. The dual-task paradigm presents advantages and potential in the assessment and cognitive training of cognitive dysfunction. The study here proposes a dual-task Stroop paradigm to identify cognitive dysfunction in high-functioning stroke patients.
General clinical cognitive assessment scales are not sensitive enough to cognitive impairment in high-functioning stroke patients. The dual-task assessment has advantages for identifying cognitive deficits in high-functioning stroke patients and has been gradually applied in clinical assessment and cognitive training. Moreover, the Stroop paradigm has higher sensitivity and specificity for attentional assessment than conventional clinical cognitive assessment scales. Therefore, this study presents the dual-task assessment based on the Stroop paradigm to identify cognitive deficits in high-functioning stroke patients. This study demonstrates a single- and dual-task evaluation based on the Stroop paradigm and confirms its feasibility through case experiments and synchronized functional near-infrared spectroscopy evaluation. The Stroop reaction time and correct rate are used as the main indicators to evaluate the cognitive level of the subjects. This study protocol aims to provide new ideas to figure out the ceiling effect in general clinical assessment failure for high-functioning stroke patients.
Stroke is the leading cause of disability in humans1 and can cause varying degrees of motor, cognitive, emotional, and other functional deficits2. Some stroke patients with better prognosis and only slight functional defects show greater functional autonomy in daily activities, but the functional state of their disability may not be sufficient to support their return to work or previous activities. These patients are referred to as high-functioning stroke patients3,4. Due to their minor functional deficits, it is hard to identify their dysfunctions, especially in terms of cognitive functions, through the general assessment of function scales, such as the Montreal cognitive assessment (MoCA)5 and clinical dementia rating (CDR)6, which have a ceiling effect and poor sensitivity for identifying mild functional defects in high-functioning stroke patients. Therefore, it is necessary to develop objective and simple methods to identify cognitive dysfunction in high-functioning stroke patients.
In recent years, the advantages of the dual-task paradigm in assessment and training have gradually become valued7,8. For example, patients may perform normally on simple cognitive single tasks (e.g., calculation) but show varying degrees of cognitive decline when additional tasks are added9,10 (e.g., walking while counting). Manaf et al. found that stroke patients often use compensatory strategies when performing cognitive-motor dual tasks, such as maintaining stability by sacrificing cognitive task performance11. Therefore, the dual-task assessment may have advantages in identifying cognitive deficits in patients with high-functioning stroke. On the one hand, the content of the dual-task assessment is closer to daily life than a single task, such as walking while observing the surrounding environment or talking and calling. In previous studies, the walking + naming task and walking + crossing obstacles task were designed to simulate walking in real environments12.
On the other hand, the executive ability in dual tasks has a close relationship with divided attention (belonging to the category of advanced cognitive function)13. Divided attention is the ability to handle multiple tasks simultaneously and allocate attention to two or more tasks14. This cognitive skill is of great significance to improve the efficiency of daily activities. Therefore, the results of the dual-task assessment can be used for reflecting the individual's divided attention. Normally, people can deal with two or more simple tasks simultaneously in their daily lives and are not disturbed. However, when brain function is impaired, there may be more dual-task interference when faced with simple dual tasks; that is, when performing dual tasks, the reduced divided attention may be likely to cause the performance of one or two tasks to be impaired15. It is concluded that dual-task execution is more likely to be able to detect advanced cognitive function impairment in patients with high-functioning stroke.
The Stroop paradigm is a classical experimental paradigm to study the Stroop effect (also known as the conflict effect)16, which has been widely used in attention assessment in cognitive function tests, especially in the field of attention inhibition17. The classical Stroop effect refers to the fact that it is difficult for individuals to respond quickly and accurately to non-dominant stimuli due to the interference of the dominant response. This results in a longer response time and lower response accuracy for non-dominant stimuli. The difference in reaction time or accuracy rate between dominant and non-dominant reactions is the Stroop effect18. Therefore, the Stroop requires high levels of attention19. Smaller Stroop effects represent higher attentional inhibition, while larger Stroop effects represent a decline in attentional inhibition18.
The Stroop paradigm may be more suitable for assessing cognitive dysfunction in patients with high-functioning stroke and has higher sensitivity and specificity for attention assessment than the traditional clinical assessment scale20. Therefore, this study designed a dual-task assessment based on the Stroop paradigm to identify cognitive deficits in high-functioning stroke patients. The protocol also includes clinical assessment of cognitive function, lower limb motor function, and balance function in stroke patients to ensure that patients can complete the dual-task assessment. Functional near-infrared spectroscopy (fNIRS) was used as an objective evaluation tool for brain function to detect the activation of brain function in high-functioning stroke patients under the dual task. The effectiveness and feasibility of the dual-task assessment scheme based on the Stroop paradigm were verified from the perspective of neuroimaging, which provides new aspects for clinical practice.
This project was approved by the Medical Ethics Association of the Fifth Affiliated Hospital of Guangzhou Medical University (No. KY01-2020-08-06) and has been registered at the China Clinical Trial Registration Center (No. ChiCTR2000036514). Informed consent was obtained from patients for using their data in this study.
1. Recruitment
2. Clinical evaluation
3. Stroop task evaluations
4. fNIRS evaluation
5. Data processing and analysis
This study presents results from a high-functioning stroke patient, who was a 71-year-old male who suffered from ischemic stroke with left hemiplegia 2 years ago. The magnetic resonance imaging (MRI) presented bilateral chronic infarction from the basal ganglia to the radiating crown. He was able to walk and live independently in the community but was not satisfied with his cognitive recovery. However, the functional assessments were all within the normal range: FMA = 100, BBS = 56/56, TUGT = 6, MoCA = 26/30, CDR = 0.5, ...
In our study, the results of the routine clinical cognitive assessment scales for the high-functioning stroke patient did not show any significant cognitive deficits. However, these assessment scales might show a ceiling effect and be less sensitive for identifying the mild cognitive deficits of high-functioning stroke patients. Hence, this protocol further selected ACC and RT in dual-task assessment based on the Stroop paradigm as major indicators to identify the cognitive deficits of high-functioning stroke patients. T...
The authors have nothing to disclose.
This study was supported by grants from the National Natural Science Foundation of China (No. 81804004, 81902281), China Postdoctoral Science Foundation (No. 2018M643207), Shenzhen Municipal Health Commission Project (No. SZBC2018005), Shenzhen Science and Technology Project (No. JCYJ20160428174825490), the General Guidance Program of Guangzhou Municipal Health and Family Planning (No. 20211A010079, 20211A011106), Guangzhou and University Foundation (No. 202102010100), Guangzhou Medical University Foundation (No. PX-66221494), Key Laboratory of Guangdong Higher Education Institutes [Grant Number: 2021KSYS009] and Guangdong Province Department of Education [Grant Number: 2021ZDZX2063].
Name | Company | Catalog Number | Comments |
Balance Ball | Shanghai Fanglian Industrial Co, China | PVC-KXZ-EVA01-2015 | NA |
E-Prime 3.0 | Psychology softwares Tools | commercial stimulus presentation software | |
fNIRS | Hui Chuang, China | NirSmart-500 | NA |
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