Jukka Takala

Delayed heart perforation after blunt trauma.

Dangers of growth hormone therapy in critically ill patients.

ARDS. Monitoring tissue perfusion.

Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients.

Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patients.

Jejunal luminal microdialysate lactate in cardiac tamponade--effect of low systemic blood flow on gut mucosa.

Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs.

Safe long-distance interhospital ground transfer of critically ill patients with acute severe unstable respiratory and circulatory failure.

Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler.

Pulmonary capillary pressure.

Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction.

Pulmonary capillary pressures during the acute respiratory distress syndrome.

Diagnosis and management of electrolyte emergencies.

Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).

Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.

Severe hypercapnia due to pulmonary embolism of polymethylmethacrylate during vertebroplasty.

Changes in splanchnic circulation during an alveolar recruitment maneuver in healthy porcine lungs.

A european, multicenter, observational study to assess the value of gastric-to-end tidal PCO2 difference in predicting postoperative complications.

Measuring depth of sedation with auditory evoked potentials during controlled infusion of propofol and remifentanil in healthy volunteers.

Estimation of central venous pressure by ultrasound.

Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion.

Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.

Comparison of continuous and intermittent renal replacement therapy for acute renal failure.

High-frequency ventilation versus conventional ventilation for the treatment of acute lung injury and acute respiratory distress syndrome: a systematic review and cochrane analysis.

Does fluid loading influence measurements of intestinal permeability?

Severe transfusion-related acute lung injury.

Moving knowledge of global burden into preventive action.

Review of estimates of the global burden of injury and illness due to occupational exposures.

Highs and lows in high-risk surgery: the controversy of goal-directed haemodynamic management.

Tracheal tear and tension pneumothorax complicating bronchoscopy-guided percutaneous tracheostomy.

A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis.

Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs.

Ethicalization in bioscience--a pilot study in Finland.

Decreasing gut wall glucose as an early marker of impaired intestinal perfusion.

Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function.

Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism.

The pulmonary artery catheter: the tool versus treatments based on the tool.

Recent trends in ILO conventions related to occupational safety and health.

The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects.

Causes of death and determinants of outcome in critically ill patients.

Global estimates of fatal work-related diseases.

Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study.

Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro.

The ratification status of ILO conventions related to occupational safety and health and its relationship with reported occupational fatality rates.

Hypoxemia due to increased venous admixture: influence of cardiac output on oxygenation.

Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock.

Variability in outcome and resource use in intensive care units.

Intraperitoneal microdialysis: critique of an editorial.

Hemodynamic management of the critically ill patient: craft meets science.

Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial.

Tonometry revisited: perfusion-related, metabolic, and respiratory components of gastric mucosal acidosis in acute cardiorespiratory failure.

Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow.

Early prognostic value of the medical emergency team calling criteria in patients admitted to intensive care from the emergency department.

The immediate and sustained effects of volume challenge on regional blood flows in pigs.

Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study.

Outcome after acute traumatic subdural and epidural haematoma in Switzerland: a single-centre experience.

Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion.

Resource use and outcome in critically ill patients with hematological malignancy: a retrospective cohort study.

Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine.

Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration.

Can outcome prediction data change patient outcomes and organizational outcomes?

Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation.

Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study.

The pulmonary artery catheter: in medio virtus.

Science, medicine and industry: are we getting out of the black hole in sepsis research?

Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow.

Better conduct of clinical trials: the control group in critical care trials.

Increased splanchnic oxygen extraction because of routine nursing procedures.

Shedding light on microcirculation?

Arterial blood pressure during early sepsis and outcome.

Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study.

Assessment of splanchnic blood flow using magnetic resonance imaging.

Different patterns of Siglec-9-mediated neutrophil death responses in septic shock.

Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study.

Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits.

Global trend according to estimated number of occupational accidents and fatal work-related diseases at region and country level.

Physical and occupational therapy during sedation stops.

Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery.

Effects of endotoxin and catecholamines on hepatic mitochondrial respiration.

Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients.

Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes.

Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure.

Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study.

When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration.

Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial.

Effect of fluid resuscitation on mortality and organ function in experimental sepsis models.

Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension.

Splanchnic vasoregulation after major abdominal surgery in pigs.

Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults.

Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions.

Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study.

Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study.

Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures.

Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model.

Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes.

Brain herniation in a patient with apparently normal intracranial pressure: a case report.

Current approach to the haemodynamic management of septic shock patients in European intensive care units: a cross-sectional, self-reported questionnaire-based survey.

Preliminary results of an ICP-controlled subarachnoid hemorrhage rabbit model for the study of delayed cerebral vasospasm.

Should we target blood pressure in sepsis?

Influenza A(H1N1) infection and severe cardiac dysfunction in adults: A case series.

Risk assessment in the first fifteen minutes: a prospective cohort study of a simple physiological scoring system in the emergency department.

Comparison of non-calibrated pulse-contour analysis with continuous thermodilution for cardiac output assessment in patients with induced hypothermia after cardiac arrest.

Hydroxyethyl starches: what do we still know?

Global estimates of fatal work-related diseases by region and disease group, 2002.

Surgery: risky business?

CO(2)-Dependent vasomotor reactivity of cerebral arteries in patients with severe traumatic brain injury: time course and effect of augmentation of cardiac output with dobutamine.

Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs.

Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial.

Identification of adequate neurally adjusted ventilatory assist (NAVA) during systematic increases in the NAVA level.

Postoperative splanchnic blood flow redistribution in response to fluid challenges in the presence and absence of endotoxemia in a porcine model.

Neurally adjusted ventilatory assist in patients with critical illness-associated polyneuromyopathy.

Impact of reimbursement schemes on quality of care: a European perspective.

Hemodynamic support: focus on monitoring tools or treatments?

Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.

Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia.

A new rabbit model for the study of early brain injury after subarachnoid hemorrhage.

Randomized, double-blind trial of the effect of fluid composition on electrolyte, acid-base, and fluid homeostasis in patients early after subarachnoid hemorrhage.

Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis.

Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes.

Haemodynamic variables and functional outcome in hypothermic patients following out-of-hospital cardiac arrest.

Continuous flow left ventricular assist devices: a valid option for heart failure patients.

Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function.

Mitochondrial function in sepsis.

Target blood pressure in sepsis: between a rock and a hard place.

Intensive care sedation: the past, present and the future.

Hemodynamic assessment of critically ill patients using a miniaturized transesophageal echocardiography probe.

Safety of modern starches used during surgery: misleading conclusions.

Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC.

No evidence for a local renin-angiotensin system in liver mitochondria.

Sedation level and prevalence of delirium: response to Brummel and Ely.

Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach.

Global estimates of the burden of injury and illness at work in 2012.

Different contribution of splanchnic organs to hyperlactatemia in fecal peritonitis and cardiac tamponade.

Left ventricular torsion abnormalities in septic shock and corrective effect of volume loading: a pilot study.

Night-time intensivists - waste of resources or failure of process optimization?

Of delirium and sedation.

Angiotensin II in septic shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis.

Clinical significance of monitoring perfusion in non-vital organs.

Reply: Is the glass of delirium half full or half empty?

Interference of angiotensin II and enalapril with hepatic blood flow regulation.

Early changes of muscle membrane properties in porcine faecal peritonitis.

Biatrial enlargement: 6,000 ml intracardiac blood volume.

Heart-lung interactions during neurally adjusted ventilatory assist.