Assam El-Osta

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation.

FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation.

On the use of DNA methylation inhibitors and the reversal of transcriptional silencing.

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer.

DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.

The rise and fall of genomic methylation in cancer.

Epigenetic changes activate widespread signals in response to double-strand breaks.

Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease.

MDR1, chemotherapy and chromatin remodeling.

Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL).

Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages.

siRNAs: mechanism of RNA interference, in vivo and potential clinical applications.

DNA damage detection and repair, and the involvement of epigenetic states.

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.

RNA interference and potential therapeutic applications of short interfering RNAs.

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.

The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X.

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.

Mechanisms of abnormal gene expression in tumor cells.

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.

The neuronal noradrenaline transporter, anxiety and cardiovascular disease.

FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle.

Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer.

The epigenetic modifier, valproic acid, enhances radiation sensitivity.

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments.

Epigenetic regulation and fetal programming.

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia.

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.

Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder.

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.

The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy.

gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci.

Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing.

Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders.

Cardiac ventricular chambers are epigenetically distinguishable.

Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons.

GammaH2AX as a molecular marker of aging and disease.

Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain.

Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms.

Glycemic memory associated epigenetic changes.

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes.

Epigenetic phenomena linked to diabetic complications.

Histone modifications regulate the norepinephrine transporter gene.

Epigenetics: mechanisms and implications for diabetic complications.

Atherogenic factors and their epigenetic relationships.

Genetic and epigenetic events in diabetic wound healing.

Double-strand breaks and the concept of short- and long-term epigenetic memory.

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.

Molecular model of naphthalene-induced DNA damage in the murine lung.

Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes.

Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities.

Remodeling is at the heart of chromatin: the heartaches of chromatin.

Chromatin modifying agents - the cutting edge of anticancer therapy.

New insights into the pathogenesis of Beckwith-Wiedemann and Silver-Russell syndromes: contribution of small copy number variations to 11p15 imprinting defects.

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.

Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis.

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease.

Glycemic memory.

Utility of γH2AX as a Molecular Marker of DNA Double-Strand Breaks in Nuclear Medicine: Applications to Radionuclide Therapy Employing Auger Electron-Emitting Isotopes.

Influence of Natural and Synthetic Histone Deacetylase Inhibitors on Chromatin.

Microparticles: major transport vehicles for distinct microRNAs in circulation.