BakerIDI Heart and Diabetes Institute,
Epigenetics in Human Health and Disease,
Baker IDI Heart and Diabetes Institute,
Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute,
Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute
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Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation.
Molecular and cellular biology Mar, 2002 | Pubmed ID: 11865062
FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation.
Biochemical and biophysical research communications Jul, 2002 | Pubmed ID: 12099676
On the use of DNA methylation inhibitors and the reversal of transcriptional silencing.
Blood Feb, 2003 | Pubmed ID: 12560246
The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer.
Experimental cell research Nov, 2003 | Pubmed ID: 14567978
DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology Nov, 2003 | Pubmed ID: 14579248
The rise and fall of genomic methylation in cancer.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K Feb, 2004 | Pubmed ID: 14628069
Epigenetic changes activate widespread signals in response to double-strand breaks.
Cancer biology & therapy Jul, 2004 | Pubmed ID: 15136760
Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease.
Cancer biology & therapy Sep, 2004 | Pubmed ID: 15326369
MDR1, chemotherapy and chromatin remodeling.
Cancer biology & therapy Sep, 2004 | Pubmed ID: 15326379
Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL).
Cancer biology & therapy Oct, 2004 | Pubmed ID: 15467427
Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages.
Journal of lipid research Feb, 2005 | Pubmed ID: 15520456
siRNAs: mechanism of RNA interference, in vivo and potential clinical applications.
Cancer biology & therapy Nov, 2004 | Pubmed ID: 15539939
DNA damage detection and repair, and the involvement of epigenetic states.
Human mutation Feb, 2005 | Pubmed ID: 15643607
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.
Nature genetics Mar, 2005 | Pubmed ID: 15696166
RNA interference and potential therapeutic applications of short interfering RNAs.
Cancer gene therapy Oct, 2005 | Pubmed ID: 15891770
Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN Aug, 2005 | Pubmed ID: 15930093
The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X.
Cancer biology & therapy Jul, 2005 | Pubmed ID: 16082178
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Oncogene Dec, 2005 | Pubmed ID: 16091741
Mechanisms of abnormal gene expression in tumor cells.
EXS , 2006 | Pubmed ID: 16383026
The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.
Cell cycle (Georgetown, Tex.) Feb, 2006 | Pubmed ID: 16418577
The neuronal noradrenaline transporter, anxiety and cardiovascular disease.
Journal of psychopharmacology (Oxford, England) Jul, 2006 | Pubmed ID: 16785272
FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle.
The Journal of biological chemistry Jul, 2007 | Pubmed ID: 17510058
Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer.
Epigenetics : official journal of the DNA Methylation Society Jul-Sep, 2006 | Pubmed ID: 17965606
The epigenetic modifier, valproic acid, enhances radiation sensitivity.
Epigenetics : official journal of the DNA Methylation Society Jul-Sep, 2006 | Pubmed ID: 17965607
Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments.
Cell cycle (Georgetown, Tex.) Feb, 2008 | Pubmed ID: 18239454
Epigenetic regulation and fetal programming.
Best practice & research. Clinical endocrinology & metabolism Feb, 2008 | Pubmed ID: 18279777
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia.
The Journal of experimental medicine Sep, 2008 | Pubmed ID: 18809715
Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.
Human molecular genetics Jan, 2009 | Pubmed ID: 18971205
Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder.
Annals of the New York Academy of Sciences Dec, 2008 | Pubmed ID: 19120127
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Diabetes May, 2009 | Pubmed ID: 19208907
The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy.
Journal of neurochemistry Jun, 2009 | Pubmed ID: 19383090
gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci.
Cellular and molecular life sciences : CMLS Jan, 2010 | Pubmed ID: 19859659
Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 19949925
Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders.
Human molecular genetics Mar, 2010 | Pubmed ID: 20007505
Cardiac ventricular chambers are epigenetically distinguishable.
Cell cycle (Georgetown, Tex.) Feb, 2010 | Pubmed ID: 20090419
Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2010 | Pubmed ID: 20107077
GammaH2AX as a molecular marker of aging and disease.
Epigenetics : official journal of the DNA Methylation Society Feb, 2010 | Pubmed ID: 20150765
Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain.
BMC neuroscience , 2010 | Pubmed ID: 20420693
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms.
Nature reviews. Nephrology Jun, 2010 | Pubmed ID: 20421885
Glycemic memory associated epigenetic changes.
Biochemical pharmacology Dec, 2010 | Pubmed ID: 20599797
Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes.
Aging Oct, 2010 | Pubmed ID: 20930262
Epigenetic phenomena linked to diabetic complications.
Nature reviews. Endocrinology Dec, 2010 | Pubmed ID: 21045787
Histone modifications regulate the norepinephrine transporter gene.
Cell cycle (Georgetown, Tex.) Nov, 2010 | Pubmed ID: 21088495
Epigenetics: mechanisms and implications for diabetic complications.
Circulation research Dec, 2010 | Pubmed ID: 21148447
Atherogenic factors and their epigenetic relationships.
International journal of vascular medicine , 2010 | Pubmed ID: 21152193
Genetic and epigenetic events in diabetic wound healing.
International wound journal Feb, 2011 | Pubmed ID: 21159125
Double-strand breaks and the concept of short- and long-term epigenetic memory.
Chromosoma Apr, 2011 | Pubmed ID: 21174214
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.
Molecular and cellular endocrinology Mar, 2011 | Pubmed ID: 21241768
Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.
Genome integrity , 2011 | Pubmed ID: 21261999
Molecular model of naphthalene-induced DNA damage in the murine lung.
Human & experimental toxicology Jan, 2012 | Pubmed ID: 21508073
Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes.
Cellular and molecular life sciences : CMLS Dec, 2011 | Pubmed ID: 21584806
Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities.
Epigenetics : official journal of the DNA Methylation Society Jun, 2011 | Pubmed ID: 21586902
Remodeling is at the heart of chromatin: the heartaches of chromatin.
Epigenetics : official journal of the DNA Methylation Society Jul, 2011 | Pubmed ID: 21646860
Chromatin modifying agents - the cutting edge of anticancer therapy.
Drug discovery today Jul, 2011 | Pubmed ID: 21664485
New insights into the pathogenesis of Beckwith-Wiedemann and Silver-Russell syndromes: contribution of small copy number variations to 11p15 imprinting defects.
Human mutation Oct, 2011 | Pubmed ID: 21780245
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.
Genome research Oct, 2011 | Pubmed ID: 21890681
Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.
Diabetes Nov, 2011 | Pubmed ID: 21896933
Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis.
Genes & nutrition Sep, 2011 | Pubmed ID: 21953375
Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease.
Epigenetics : official journal of the DNA Methylation Society Dec, 2011 | Pubmed ID: 22139576
Glycemic memory.
Current opinion in lipidology Feb, 2012 | Pubmed ID: 22186662
Utility of γH2AX as a Molecular Marker of DNA Double-Strand Breaks in Nuclear Medicine: Applications to Radionuclide Therapy Employing Auger Electron-Emitting Isotopes.
Current radiopharmaceuticals Jan, 2011 | Pubmed ID: 22191615
Influence of Natural and Synthetic Histone Deacetylase Inhibitors on Chromatin.
Antioxidants & redox signaling Feb, 2012 | Pubmed ID: 22229817
Microparticles: major transport vehicles for distinct microRNAs in circulation.
Cardiovascular research Feb, 2012 | Pubmed ID: 22258631
Li-Jeen Mah1,2,
Raja S. Vasireddy1,2,3,
Michelle M. Tang1,3,
George T. Georgiadis1,
Assam El-Osta2,3,
Tom C. Karagiannis1,2
1Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct,
2Department of Pathology, The University of Melbourne,
3Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct
Michelle M. Tang1,2,
Li-Jeen Mah1,3,
Raja S. Vasireddy1,2,3,
George T. Georgiadis1,
Assam El-Osta2,3,
Simon G. Royce3,4,5,
Tom C. Karagiannis1,3
1Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct,
2Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct,
3Department of Pathology, The University of Melbourne,
4Department of Allergy and Immunology, Murdoch Children's Research Institute, Royal Children's Hospital,
5Department of Pediatrics, The University of Melbourne
Haloom Rafehi1,2,
Christian Orlowski1,2,3,
George T. Georgiadis1,
Katherine Ververis1,4,
Assam El-Osta2,3,
Tom C. Karagiannis1,2
1Epigenomic Medicine, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct,
2Department of Pathology, The University of Melbourne,
3Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct,
4Department of Anatomy and Cellular Biology, The University of Melbourne
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