Irwin Davidson

Synergistic transcriptional activation by TATA-binding protein and hTAFII28 requires specific amino acids of the hTAFII28 histone fold.

Human TAF(II)55 interacts with the vitamin D(3) and thyroid hormone receptors and with derivatives of the retinoid X receptor that have altered transactivation properties.

The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs.

Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7.

The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.

Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids.

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.

Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain.

Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).

RNA polymerase II transcription in murine cells lacking the TATA binding protein.

The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.

The genetics of TBP and TBP-related factors.

[TBP, a universal transcription factor?].

Testis-specific transcription mechanisms promoting male germ-cell differentiation.

Cell-specific nucleolar localization of TBP-related factor 2.

Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis.

Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells.

TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth.

Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis.

New insights into TAFs as regulators of cell cycle and signaling pathways.

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.

TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1.

Specialization of the general transcriptional machinery in male germ cells.

Recent advances in understanding the structure and function of general transcription factor TFIID.

Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells.

Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene.

Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.

seqMINER: an integrated ChIP-seq data interpretation platform.

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.

Front seat and back seat drivers of melanoma metastasis.

Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.

The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression.

Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.

Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.

Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA.

MITF, the Janus transcription factor of melanoma.

Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation.

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

Structural basis of natural promoter recognition by the retinoid X nuclear receptor.

No evidence for generation of alternatively spliced isoforms from the mutated Trim24 allele lacking exon 4 in mouse liver.

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice.

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells.

A Brn2-Zic1 axis specifies the neuronal fate of retinoic-acid-treated embryonic stem cells.

MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma.

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells.

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.

TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation.

T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.

Melanoma addiction to the long non-coding RNA SAMMSON.

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.

TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.

Macrophage production and activation are dependent on TRIM33.

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.

Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly.

Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.

MITF-high and MITF-low cells and a novel subpopulation expressing genes of both cell states contribute to intra and inter-tumoral heterogeneity of primary melanoma.