Eric Jenkinson

Induction of thymocyte positive selection does not convey immediate resistance to negative selection.

Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors.

Microenvironmental regulation of Notch signalling in T cell development.

Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.

Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.

Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors.

Thymic epithelial cells provide WNT signals to developing thymocytes.

Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.

Modeling TCR signaling complex formation in positive selection.

A stroma-derived defect in NF-kappaB2-/- mice causes impaired lymph node development and lymphocyte recruitment.

T/B lineage choice occurs prior to intrathymic Notch signaling.

OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression.

Development of functional thymic epithelial cells occurs independently of lymphostromal interactions.

Establishment and functioning of intrathymic microenvironments.

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.

The thymus and T-cell commitment: the right niche for Notch?

Overexpression of ICAT highlights a role for catenin-mediated canonical Wnt signalling in early T cell development.

Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).

PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches.

Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.

Chemokine receptor expression defines heterogeneity in the earliest thymic migrants.

CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.

EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.

Redefining epithelial progenitor potential in the developing thymus.

Investigating central tolerance with reaggregate thymus organ cultures.

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

Generating intrathymic microenvironments to establish T-cell tolerance.

Role of CD30 in B/T segregation in the spleen.

Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.

An epithelial progenitor pool regulates thymus growth.

Bringing the thymus to the bench.

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.

Checkpoints in the development of thymic cortical epithelial cells.

A roadmap for thymic epithelial cell development.

Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult.

Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival.

Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.

Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.

Fetal thymus organ culture.

Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.

Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.

Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.

A novel method to allow non-invasive, longitudinal imaging of the murine immune system in vivo.