Graham Anderson

Induction of thymocyte positive selection does not convey immediate resistance to negative selection.

One for all and all for one: thymic epithelial stem cells and regeneration.

Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors.

Microenvironmental regulation of Notch signalling in T cell development.

Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.

A comparison of eccentric isokinetic torque production and velocity of knee flexion angle during step down in patellofemoral pain syndrome patients and unaffected subjects.

Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.

Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors.

Thymic epithelial cells provide WNT signals to developing thymocytes.

Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.

Modeling TCR signaling complex formation in positive selection.

A stroma-derived defect in NF-kappaB2-/- mice causes impaired lymph node development and lymphocyte recruitment.

Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells.

T/B lineage choice occurs prior to intrathymic Notch signaling.

OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression.

Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs.

Development of functional thymic epithelial cells occurs independently of lymphostromal interactions.

Establishment and functioning of intrathymic microenvironments.

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.

The thymus and T-cell commitment: the right niche for Notch?

Overexpression of ICAT highlights a role for catenin-mediated canonical Wnt signalling in early T cell development.

Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).

PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches.

Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.

Chemokine receptor expression defines heterogeneity in the earliest thymic migrants.

CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.

EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.

Redefining epithelial progenitor potential in the developing thymus.

Investigating central tolerance with reaggregate thymus organ cultures.

Involvement of CCR9 at multiple stages of adult T lymphopoiesis.

The role of lymphoid tissue inducer cells in splenic white pulp development.

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

Generating intrathymic microenvironments to establish T-cell tolerance.

Role of CD30 in B/T segregation in the spleen.

Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.

Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella.

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.

Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses.

Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection.

Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.

An epithelial progenitor pool regulates thymus growth.

Bringing the thymus to the bench.

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.

Checkpoints in the development of thymic cortical epithelial cells.

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.

CD30 is required for CCL21 expression and CD4 T cell recruitment in the absence of lymphotoxin signals.

The Global Thymus Network: past, present and future.

A roadmap for thymic epithelial cell development.

Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge.

Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult.

NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism.

The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals.

Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival.

Ontogeny of stromal organizer cells during lymph node development.

Cis-interactions between Notch and Delta generate mutually exclusive signalling states.

The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.

Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.

A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis.

Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses.

Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.

Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells.

Fetal thymus organ culture.

Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.

Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.

CD117⁺ CD3⁻ CD56⁻ OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues.

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.

Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos.

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function.

Lymphoid tissue inducer cells: innate cells critical for CD4(+) T cell memory responses?

A novel method to allow non-invasive, longitudinal imaging of the murine immune system in vivo.