MRC Center for Immune Regulation
Eric Jenkinson has not added Biography.
If you are Eric Jenkinson and would like to personalize this page please email our Author Liaison for assistance.
Induction of thymocyte positive selection does not convey immediate resistance to negative selection.
Immunology Feb, 2002 | Pubmed ID: 11872091
Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2003 | Pubmed ID: 12538689
Microenvironmental regulation of Notch signalling in T cell development.
Seminars in immunology Apr, 2003 | Pubmed ID: 12681945
Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.
Molecular immunology Jun, 2003 | Pubmed ID: 12749908
Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2003 | Pubmed ID: 12847211
Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors.
The Journal of experimental medicine Jul, 2003 | Pubmed ID: 12860931
Thymic epithelial cells provide WNT signals to developing thymocytes.
European journal of immunology Jul, 2003 | Pubmed ID: 12884861
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.
The EMBO journal Sep, 2003 | Pubmed ID: 12941699
Modeling TCR signaling complex formation in positive selection.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12960303
A stroma-derived defect in NF-kappaB2-/- mice causes impaired lymph node development and lymphocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2004 | Pubmed ID: 15294939
T/B lineage choice occurs prior to intrathymic Notch signaling.
Blood Aug, 2005 | Pubmed ID: 15845899
OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2005 | Pubmed ID: 15905508
Development of functional thymic epithelial cells occurs independently of lymphostromal interactions.
Mechanisms of development Dec, 2005 | Pubmed ID: 16274965
Establishment and functioning of intrathymic microenvironments.
Immunological reviews Feb, 2006 | Pubmed ID: 16448531
Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.
Nature Jun, 2006 | Pubmed ID: 16791197
The thymus and T-cell commitment: the right niche for Notch?
Nature reviews. Immunology Jul, 2006 | Pubmed ID: 16799474
Overexpression of ICAT highlights a role for catenin-mediated canonical Wnt signalling in early T cell development.
European journal of immunology Sep, 2006 | Pubmed ID: 16897815
Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).
Journal of immunology (Baltimore, Md. : 1950) Sep, 2006 | Pubmed ID: 16920944
PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches.
Blood Feb, 2007 | Pubmed ID: 17008543
Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.
Blood Feb, 2007 | Pubmed ID: 17018858
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine Jun, 2007 | Pubmed ID: 17502664
Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.
Blood Sep, 2007 | Pubmed ID: 17526859
Chemokine receptor expression defines heterogeneity in the earliest thymic migrants.
European journal of immunology Aug, 2007 | Pubmed ID: 17578846
CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.
FEBS letters Jul, 2007 | Pubmed ID: 17628549
EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.
European journal of immunology Sep, 2007 | Pubmed ID: 17668899
Redefining epithelial progenitor potential in the developing thymus.
European journal of immunology Sep, 2007 | Pubmed ID: 17694573
Investigating central tolerance with reaggregate thymus organ cultures.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 17876094
AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.
The Journal of biological chemistry Jan, 2008 | Pubmed ID: 17974569
Generating intrathymic microenvironments to establish T-cell tolerance.
Nature reviews. Immunology Dec, 2007 | Pubmed ID: 17992179
Role of CD30 in B/T segregation in the spleen.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2007 | Pubmed ID: 18025198
Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.
Immunology Jun, 2008 | Pubmed ID: 18205791
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.
European journal of immunology Apr, 2008 | Pubmed ID: 18350550
TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.
PLoS biology Aug, 2008 | Pubmed ID: 18684012
An epithelial progenitor pool regulates thymus growth.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2008 | Pubmed ID: 18941199
Bringing the thymus to the bench.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2008 | Pubmed ID: 19017928
Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.
European journal of immunology Jan, 2009 | Pubmed ID: 19089813
Checkpoints in the development of thymic cortical epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2009 | Pubmed ID: 19109143
A roadmap for thymic epithelial cell development.
European journal of immunology Jul, 2009 | Pubmed ID: 19582736
Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult.
European journal of immunology Sep, 2009 | Pubmed ID: 19662637
Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival.
European journal of immunology Feb, 2010 | Pubmed ID: 19950181
Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
PloS one , 2010 | Pubmed ID: 20502698
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20861360
Fetal thymus organ culture.
CSH protocols , 2007 | Pubmed ID: 21357146
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950) May, 2011 | Pubmed ID: 21421850
Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.
Rejuvenation research Jun, 2011 | Pubmed ID: 21453014
Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.
Mechanisms of ageing and development May, 2011 | Pubmed ID: 21549744
A novel method to allow non-invasive, longitudinal imaging of the murine immune system in vivo.
Blood Jan, 2012 | Pubmed ID: 22271449
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved