MRC Center for Immune Regulation
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Induction of thymocyte positive selection does not convey immediate resistance to negative selection.
Immunology Feb, 2002 | Pubmed ID: 11872091
One for all and all for one: thymic epithelial stem cells and regeneration.
Trends in immunology Aug, 2002 | Pubmed ID: 12133801
Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2003 | Pubmed ID: 12538689
Microenvironmental regulation of Notch signalling in T cell development.
Seminars in immunology Apr, 2003 | Pubmed ID: 12681945
Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.
Molecular immunology Jun, 2003 | Pubmed ID: 12749908
A comparison of eccentric isokinetic torque production and velocity of knee flexion angle during step down in patellofemoral pain syndrome patients and unaffected subjects.
Clinical biomechanics (Bristol, Avon) Jul, 2003 | Pubmed ID: 12828898
Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2003 | Pubmed ID: 12847211
Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors.
The Journal of experimental medicine Jul, 2003 | Pubmed ID: 12860931
Thymic epithelial cells provide WNT signals to developing thymocytes.
European journal of immunology Jul, 2003 | Pubmed ID: 12884861
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.
The EMBO journal Sep, 2003 | Pubmed ID: 12941699
Modeling TCR signaling complex formation in positive selection.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12960303
A stroma-derived defect in NF-kappaB2-/- mice causes impaired lymph node development and lymphocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2004 | Pubmed ID: 15294939
Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells.
Journal of immunology (Baltimore, Md. : 1950) May, 2005 | Pubmed ID: 15843540
T/B lineage choice occurs prior to intrathymic Notch signaling.
Blood Aug, 2005 | Pubmed ID: 15845899
OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2005 | Pubmed ID: 15905508
Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs.
International immunology Sep, 2005 | Pubmed ID: 16103028
Development of functional thymic epithelial cells occurs independently of lymphostromal interactions.
Mechanisms of development Dec, 2005 | Pubmed ID: 16274965
Establishment and functioning of intrathymic microenvironments.
Immunological reviews Feb, 2006 | Pubmed ID: 16448531
Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.
Nature Jun, 2006 | Pubmed ID: 16791197
The thymus and T-cell commitment: the right niche for Notch?
Nature reviews. Immunology Jul, 2006 | Pubmed ID: 16799474
Overexpression of ICAT highlights a role for catenin-mediated canonical Wnt signalling in early T cell development.
European journal of immunology Sep, 2006 | Pubmed ID: 16897815
Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).
Journal of immunology (Baltimore, Md. : 1950) Sep, 2006 | Pubmed ID: 16920944
PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches.
Blood Feb, 2007 | Pubmed ID: 17008543
Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.
Blood Feb, 2007 | Pubmed ID: 17018858
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine Jun, 2007 | Pubmed ID: 17502664
Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.
Blood Sep, 2007 | Pubmed ID: 17526859
Chemokine receptor expression defines heterogeneity in the earliest thymic migrants.
European journal of immunology Aug, 2007 | Pubmed ID: 17578846
CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.
FEBS letters Jul, 2007 | Pubmed ID: 17628549
EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.
European journal of immunology Sep, 2007 | Pubmed ID: 17668899
Redefining epithelial progenitor potential in the developing thymus.
European journal of immunology Sep, 2007 | Pubmed ID: 17694573
Investigating central tolerance with reaggregate thymus organ cultures.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 17876094
Involvement of CCR9 at multiple stages of adult T lymphopoiesis.
Journal of leukocyte biology Jan, 2008 | Pubmed ID: 17911179
The role of lymphoid tissue inducer cells in splenic white pulp development.
European journal of immunology Nov, 2007 | Pubmed ID: 17948268
AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.
The Journal of biological chemistry Jan, 2008 | Pubmed ID: 17974569
Generating intrathymic microenvironments to establish T-cell tolerance.
Nature reviews. Immunology Dec, 2007 | Pubmed ID: 17992179
Role of CD30 in B/T segregation in the spleen.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2007 | Pubmed ID: 18025198
Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.
Immunology Jun, 2008 | Pubmed ID: 18205791
Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2008 | Pubmed ID: 18292503
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.
European journal of immunology Apr, 2008 | Pubmed ID: 18350550
Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses.
Seminars in immunology Jun, 2008 | Pubmed ID: 18407516
Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950) May, 2008 | Pubmed ID: 18453597
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.
Cell Jun, 2008 | Pubmed ID: 18555784
TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.
PLoS biology Aug, 2008 | Pubmed ID: 18684012
An epithelial progenitor pool regulates thymus growth.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2008 | Pubmed ID: 18941199
Bringing the thymus to the bench.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2008 | Pubmed ID: 19017928
Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.
European journal of immunology Jan, 2009 | Pubmed ID: 19089813
Checkpoints in the development of thymic cortical epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2009 | Pubmed ID: 19109143
Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Immunity Feb, 2009 | Pubmed ID: 19217324
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19218450
CD30 is required for CCL21 expression and CD4 T cell recruitment in the absence of lymphotoxin signals.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2009 | Pubmed ID: 19342654
The Global Thymus Network: past, present and future.
Trends in immunology May, 2009 | Pubmed ID: 19362055
A roadmap for thymic epithelial cell development.
European journal of immunology Jul, 2009 | Pubmed ID: 19582736
Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge.
European journal of immunology Aug, 2009 | Pubmed ID: 19609980
Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult.
European journal of immunology Sep, 2009 | Pubmed ID: 19662637
NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism.
European journal of immunology Oct, 2009 | Pubmed ID: 19731363
The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2009 | Pubmed ID: 19786532
Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival.
European journal of immunology Feb, 2010 | Pubmed ID: 19950181
Ontogeny of stromal organizer cells during lymph node development.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2010 | Pubmed ID: 20237296
Cis-interactions between Notch and Delta generate mutually exclusive signalling states.
Nature May, 2010 | Pubmed ID: 20418862
The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.
European journal of immunology Jul, 2010 | Pubmed ID: 20432232
Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
PloS one , 2010 | Pubmed ID: 20502698
A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis.
FEBS letters Sep, 2010 | Pubmed ID: 20682314
Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses.
Progress in molecular biology and translational science , 2010 | Pubmed ID: 20800820
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20861360
Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells.
The Journal of clinical investigation Feb, 2011 | Pubmed ID: 21206088
Fetal thymus organ culture.
CSH protocols , 2007 | Pubmed ID: 21357146
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950) May, 2011 | Pubmed ID: 21421850
Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.
Rejuvenation research Jun, 2011 | Pubmed ID: 21453014
CD117⺠CD3⻠CD56⻠OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues.
European journal of immunology Jun, 2011 | Pubmed ID: 21469096
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Science (New York, N.Y.) Apr, 2011 | Pubmed ID: 21474713
Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.
Mechanisms of ageing and development May, 2011 | Pubmed ID: 21549744
Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos.
Journal of cell science Jun, 2011 | Pubmed ID: 21610091
Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.
The Journal of experimental medicine Aug, 2011 | Pubmed ID: 21788408
OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function.
Immunological reviews Nov, 2011 | Pubmed ID: 22017436
Lymphoid tissue inducer cells: innate cells critical for CD4(+) T cell memory responses?
Annals of the New York Academy of Sciences Jan, 2012 | Pubmed ID: 22260374
A novel method to allow non-invasive, longitudinal imaging of the murine immune system in vivo.
Blood Jan, 2012 | Pubmed ID: 22271449
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