Laboratory of Molecular Immunology,
Howard Hughes Medical Institute
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Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell Jun, 2015 | Pubmed ID: 26004070
Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2011 | Pubmed ID: 22025722
Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements.
Journal of immunological methods Jan, 2012 | Pubmed ID: 22033343
Polyreactive antibodies in adaptive immune responses to viruses.
Cellular and molecular life sciences : CMLS May, 2012 | Pubmed ID: 22045557
Enhanced HIV-1 neutralization by antibody heteroligation.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2012 | Pubmed ID: 22219363
Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.
Advances in cancer research , 2012 | Pubmed ID: 22429855
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.
The Journal of experimental medicine Jun, 2012 | Pubmed ID: 22615130
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.
The Journal of experimental medicine Jul, 2012 | Pubmed ID: 22826297
Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.
The Journal of experimental medicine Aug, 2012 | Pubmed ID: 22851594
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
The EMBO journal Oct, 2012 | Pubmed ID: 22940690
Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase.
Annual review of pathology Jan, 2013 | Pubmed ID: 22974238
DEC-205 is a cell surface receptor for CpG oligonucleotides.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2012 | Pubmed ID: 22988114
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry.
Nature immunology Nov, 2012 | Pubmed ID: 23001145
A mouse model for HIV-1 entry.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2012 | Pubmed ID: 23019371
A Blueprint for HIV Vaccine Discovery.
Cell host & microbe Oct, 2012 | Pubmed ID: 23084910
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
Nature Dec, 2012 | Pubmed ID: 23103874
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2012 | Pubmed ID: 23115339
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
The Journal of experimental medicine Jan, 2013 | Pubmed ID: 23254285
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle.
Cell reports Jan, 2013 | Pubmed ID: 23291097
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science (New York, N.Y.) Feb, 2013 | Pubmed ID: 23306439
Role of 53BP1 oligomerization in regulating double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2013 | Pubmed ID: 23345425
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23524883
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell Mar, 2013 | Pubmed ID: 23540694
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.
Nature medicine Jun, 2013 | Pubmed ID: 23685841
Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.
The Journal of experimental medicine Jun, 2013 | Pubmed ID: 23712429
High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration.
Journal of virology Aug, 2013 | Pubmed ID: 23720718
Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model.
Journal of virology Aug, 2013 | Pubmed ID: 23720722
Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2013 | Pubmed ID: 23754383
Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains.
Journal of virology Sep, 2013 | Pubmed ID: 23843642
Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.
PloS one , 2013 | Pubmed ID: 23861962
T follicular helper cell dynamics in germinal centers.
Science (New York, N.Y.) Aug, 2013 | Pubmed ID: 23887872
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.
Immunity Aug, 2013 | Pubmed ID: 23911655
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology Sep, 2013 | Pubmed ID: 23913046
The origin of B cell recurrent chromosomal translocations: proximity versus DNA damage.
Molecular cell Aug, 2013 | Pubmed ID: 23932709
Antibodies in HIV-1 vaccine development and therapy.
Science (New York, N.Y.) Sep, 2013 | Pubmed ID: 24031012
Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160Δc(BaL.).
Journal of immunological methods Nov, 2013 | Pubmed ID: 24041474
Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.
The Journal of experimental medicine Sep, 2013 | Pubmed ID: 24043764
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2013 | Pubmed ID: 24043801
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
Nature Nov, 2013 | Pubmed ID: 24172896
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Nature Nov, 2013 | Pubmed ID: 24172905
Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission.
The Journal of experimental medicine Dec, 2013 | Pubmed ID: 24277152
L-Myc expression by dendritic cells is required for optimal T-cell priming.
Nature Mar, 2014 | Pubmed ID: 24509714
Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
Cell Feb, 2014 | Pubmed ID: 24529371
Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike.
Cell reports May, 2014 | Pubmed ID: 24767986
Clonal selection in the germinal centre by regulated proliferation and hypermutation.
Nature May, 2014 | Pubmed ID: 24805232
Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2014 | Pubmed ID: 24829411
Identification of chromosomal translocation hotspots via scan statistics.
Bioinformatics (Oxford, England) Sep, 2014 | Pubmed ID: 24860160
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.
Cell Aug, 2014 | Pubmed ID: 25131989
Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.
The Journal of experimental medicine Aug, 2014 | Pubmed ID: 25135299
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
The Journal of experimental medicine Sep, 2014 | Pubmed ID: 25155019
Dynamic signaling by T follicular helper cells during germinal center B cell selection.
Science (New York, N.Y.) Aug, 2014 | Pubmed ID: 25170154
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity.
Cell Sep, 2014 | Pubmed ID: 25215485
An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.
The Journal of allergy and clinical immunology Apr, 2015 | Pubmed ID: 25312759
A robust pipeline for rapid production of versatile nanobody repertoires.
Nature methods Dec, 2014 | Pubmed ID: 25362362
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.
The Journal of experimental medicine Nov, 2014 | Pubmed ID: 25385756
Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.
Cell Dec, 2014 | Pubmed ID: 25483776
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Cell Dec, 2014 | Pubmed ID: 25483777
Epigenetic targeting of activation-induced cytidine deaminase.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25512519
Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes.
Journal of virology Mar, 2015 | Pubmed ID: 25520506
HIV-1 integration landscape during latent and active infection.
Cell Jan, 2015 | Pubmed ID: 25635456
Intra-spike crosslinking overcomes antibody evasion by HIV-1.
Cell Jan, 2015 | Pubmed ID: 25635457
Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient.
Journal of immunological methods Mar, 2015 | Pubmed ID: 25667013
Circulating precursors of human CD1c+ and CD141+ dendritic cells.
The Journal of experimental medicine Mar, 2015 | Pubmed ID: 25687281
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.
The Journal of experimental medicine Mar, 2015 | Pubmed ID: 25687283
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
Nature Mar, 2015 | Pubmed ID: 25707797
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.
Nature Jun, 2015 | Pubmed ID: 25855300
Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.
mBio Apr, 2015 | Pubmed ID: 25900654
Clonal analysis of human dendritic cell progenitor using a stromal cell culture.
Journal of immunological methods Oct, 2015 | Pubmed ID: 26056939
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.
Cell Jun, 2015 | Pubmed ID: 26091035
HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.
Science (New York, N.Y.) Aug, 2015 | Pubmed ID: 26184917
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.
Cell Aug, 2015 | Pubmed ID: 26276629
Defining human dendritic cell progenitors by multiparametric flow cytometry.
Nature protocols Sep, 2015 | Pubmed ID: 26292072
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.
Nature Sep, 2015 | Pubmed ID: 26308889
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nature communications Sep, 2015 | Pubmed ID: 26404402
V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1.
Journal of acquired immune deficiency syndromes (1999) Mar, 2016 | Pubmed ID: 26413851
A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.
PLoS pathogens Oct, 2015 | Pubmed ID: 26516768
Towards HIV-1 remission: potential roles for broadly neutralizing antibodies.
The Journal of clinical investigation Feb, 2016 | Pubmed ID: 26752643
A New Way to Diversify Antibodies by DNA Transposition.
Cell Feb, 2016 | Pubmed ID: 26871626
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.
Nature communications Feb, 2016 | Pubmed ID: 26907590
Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory.
Immunity Apr, 2016 | Pubmed ID: 26944202
Structural basis for germline antibody recognition of HIV-1 immunogens.
eLife Mar, 2016 | Pubmed ID: 26997349
Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation.
The Journal of experimental medicine Apr, 2016 | Pubmed ID: 27001748
Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection.
PLoS pathogens Mar, 2016 | Pubmed ID: 27028935
Inducible targeting of cDCs and their subsets in vivo.
Journal of immunological methods Jul, 2016 | Pubmed ID: 27073171
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.
Nature May, 2016 | Pubmed ID: 27120156
HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.
Science (New York, N.Y.) May, 2016 | Pubmed ID: 27199429
Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.
Science (New York, N.Y.) May, 2016 | Pubmed ID: 27199430
Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency.
Cell Jun, 2016 | Pubmed ID: 27315478
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.
Nature Jul, 2016 | Pubmed ID: 27338952
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.
Cell Sep, 2016 | Pubmed ID: 27610569
Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.
Nature structural & molecular biology Oct, 2016 | Pubmed ID: 27617431
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.
Immunity Sep, 2016 | Pubmed ID: 27617678
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols Oct, 2016 | Pubmed ID: 27658009
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs.
The Journal of experimental medicine Dec, 2016 | Pubmed ID: 27864467
Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2016 | Pubmed ID: 27872306
The cell cycle restricts activation-induced cytidine deaminase activity to early G1.
The Journal of experimental medicine Jan, 2017 | Pubmed ID: 27998928
The Heterogeneity of Ly6C(hi) Monocytes Controls Their Differentiation into iNOS(+) Macrophages or Monocyte-Derived Dendritic Cells.
Immunity Dec, 2016 | Pubmed ID: 28002729
Progress toward active or passive HIV-1 vaccination.
The Journal of experimental medicine Jan, 2017 | Pubmed ID: 28003309
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.
Nature medicine Feb, 2017 | Pubmed ID: 28092665
RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.
The Journal of experimental medicine Mar, 2017 | Pubmed ID: 28179379
Early antibody therapy can induce long-lasting immunity to SHIV.
Nature Mar, 2017 | Pubmed ID: 28289286
HIV: Persistence through division.
The Journal of experimental medicine Apr, 2017 | Pubmed ID: 28348204
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
Cell May, 2017 | Pubmed ID: 28475892
Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.
eLife May, 2017 | Pubmed ID: 28548638
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.
Cell Aug, 2017 | Pubmed ID: 28757252
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.
The Journal of experimental medicine Sep, 2017 | Pubmed ID: 28847869
The microanatomic segregation of selection by apoptosis in the germinal center.
Science (New York, N.Y.) Oct, 2017 | Pubmed ID: 28935768
Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells.
Journal of virology Mar, 2018 | Pubmed ID: 29237833
Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.
PLoS pathogens Mar, 2018 | Pubmed ID: 29505593
Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
Nature communications Mar, 2018 | Pubmed ID: 29593217
Redemption for self-reactive antibodies.
Science (New York, N.Y.) Apr, 2018 | Pubmed ID: 29650658
Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity.
Proceedings of the National Academy of Sciences of the United States of America May, 2018 | Pubmed ID: 29666227
Clonal CD4 T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation.
Nature medicine May, 2018 | Pubmed ID: 29686423
Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117.
The Journal of experimental medicine Sep, 2018 | Pubmed ID: 30072495
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.
Nature immunology Sep, 2018 | Pubmed ID: 30127434
Combination therapy with anti-HIV-1 antibodies maintains viral suppression.
Nature Sep, 2018 | Pubmed ID: 30258136
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.
Nature medicine Nov, 2018 | Pubmed ID: 30258217
The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination.
Molecular cell Nov, 2018 | Pubmed ID: 30293785
Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.
Cell host & microbe Oct, 2018 | Pubmed ID: 30308160
A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.
Cell reports Nov, 2018 | Pubmed ID: 30403995
Relationship between intact HIV-1 proviruses in circulating CD4 T cells and rebound viruses emerging during treatment interruption.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2018 | Pubmed ID: 30420517
Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption.
Journal of virology 04, 2019 | Pubmed ID: 30700598
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic.
Nature medicine Apr, 2019 | Pubmed ID: 30936546
HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells.
The Journal of experimental medicine Jun, 2019 | Pubmed ID: 30975893
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.
Immunity Jun, 2019 | Pubmed ID: 31126879
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature Jun, 2019 | Pubmed ID: 31142836
Anti-idiotypic antibodies elicit anti-HIV-1-specific B cell responses.
The Journal of experimental medicine Oct, 2019 | Pubmed ID: 31345931
Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity.
Immunity Aug, 2019 | Pubmed ID: 31350178
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
Cell reports Sep, 2021 | Pubmed ID: 34534459
Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir.
The Journal of experimental medicine Oct, 2019 | Pubmed ID: 31350309
Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.
PloS one , 2019 | Pubmed ID: 31393868
Risk of Zika microcephaly correlates with features of maternal antibodies.
The Journal of experimental medicine Oct, 2019 | Pubmed ID: 31413072
Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin.
Journal of virology Feb, 2020 | Pubmed ID: 31852794
Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.
Nature medicine Feb, 2020 | Pubmed ID: 32015556
A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2020 | Pubmed ID: 32209664
Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir.
The Journal of experimental medicine Jul, 2020 | Pubmed ID: 32311008
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody.
Proceedings of the National Academy of Sciences of the United States of America May, 2020 | Pubmed ID: 32321830
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations.
Cell host & microbe Aug, 2020 | Pubmed ID: 32504577
Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals.
bioRxiv : the preprint server for biology May, 2020 | Pubmed ID: 32511384
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
Nature Aug, 2020 | Pubmed ID: 32555388
Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies.
bioRxiv : the preprint server for biology May, 2020 | Pubmed ID: 32577645
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses.
bioRxiv : the preprint server for biology Jun, 2020 | Pubmed ID: 32577658
Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies.
Nature communications Jun, 2020 | Pubmed ID: 32581216
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.
Cell Aug, 2020 | Pubmed ID: 32645326
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses.
The Journal of experimental medicine Nov, 2020 | Pubmed ID: 32692348
Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration.
Antibodies (Basel, Switzerland) Jul, 2020 | Pubmed ID: 32751063
Structural classification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain suggests vaccine and therapeutic strategies.
bioRxiv : the preprint server for biology Aug, 2020 | Pubmed ID: 32869026
Recommendations for measuring HIV reservoir size in cure-directed clinical trials.
Nature medicine Sep, 2020 | Pubmed ID: 32895573
Enhanced SARS-CoV-2 Neutralization by Secretory IgA in vitro.
bioRxiv : the preprint server for biology Sep, 2020 | Pubmed ID: 32935095
An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2020 | Pubmed ID: 32963096
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Science (New York, N.Y.) Oct, 2020 | Pubmed ID: 32972996
ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens.
Cell reports. Medicine Oct, 2020 | Pubmed ID: 32995758
Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection .
bioRxiv : the preprint server for biology Sep, 2020 | Pubmed ID: 32995782
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature Dec, 2020 | Pubmed ID: 33045718
A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch.
eLife Oct, 2020 | Pubmed ID: 33084569
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants.
eLife Oct, 2020 | Pubmed ID: 33112236
Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates.
Cell Nov, 2020 | Pubmed ID: 33125897
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo.
The Journal of experimental medicine Mar, 2021 | Pubmed ID: 33211088
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.
bioRxiv : the preprint server for biology Jan, 2021 | Pubmed ID: 33236016
Enhanced SARS-CoV-2 neutralization by dimeric IgA.
Science translational medicine Jan, 2021 | Pubmed ID: 33288661
Neutralizing Activity of Broadly Neutralizing anti-HIV-1 Antibodies against Primary African Isolates.
Journal of virology Dec, 2020 | Pubmed ID: 33298542
Persistent Cellular Immunity to SARS-CoV-2 Infection.
bioRxiv : the preprint server for biology Dec, 2020 | Pubmed ID: 33330867
Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA.
Journal of virology Feb, 2021 | Pubmed ID: 33361426
Single-Cell Sorting of HBsAg-Binding Memory B Cells from Human Peripheral Blood Mononuclear Cells and Antibody Cloning.
STAR protocols Dec, 2020 | Pubmed ID: 33377023
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.
Science (New York, N.Y.) Feb, 2021 | Pubmed ID: 33436524
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption.
Science translational medicine Jan, 2021 | Pubmed ID: 33441429
Evolution of antibody immunity to SARS-CoV-2.
Nature Mar, 2021 | Pubmed ID: 33461210
Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.
bioRxiv : the preprint server for biology Apr, 2021 | Pubmed ID: 33532765
Persistent cellular immunity to SARS-CoV-2 infection.
The Journal of experimental medicine Apr, 2021 | Pubmed ID: 33533915
Dynamic regulation of T selection during the germinal centre reaction.
Nature Mar, 2021 | Pubmed ID: 33536617
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.
Nature Apr, 2021 | Pubmed ID: 33567448
A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls.
EBioMedicine Mar, 2021 | Pubmed ID: 33640794
Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies.
bioRxiv : the preprint server for biology Mar, 2021 | Pubmed ID: 33758856
Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies.
bioRxiv : the preprint server for biology Mar, 2021 | Pubmed ID: 33758864
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.
Nature May, 2021 | Pubmed ID: 33767445
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols Jun, 2021 | Pubmed ID: 33778783
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
The Journal of experimental medicine May, 2021 | Pubmed ID: 33831141
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
bioRxiv : the preprint server for biology Apr, 2021 | Pubmed ID: 33907745
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
bioRxiv : the preprint server for biology Apr, 2021 | Pubmed ID: 33948592
Broadly neutralizing antibody-mediated protection of macaques against repeated intravenous exposures to simian-human immunodeficiency virus.
AIDS (London, England) Aug, 2021 | Pubmed ID: 33966028
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.
Nature Jul, 2021 | Pubmed ID: 34098567
Germinal center-dependent and -independent memory B cells produced throughout the immune response.
The Journal of experimental medicine Aug, 2021 | Pubmed ID: 34106207
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection.
Nature Jul, 2021 | Pubmed ID: 34126625
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.
PLoS pathogens Jul, 2021 | Pubmed ID: 34228761
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.
Nature communications Jul, 2021 | Pubmed ID: 34234131
Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.
Cell reports Jul, 2021 | Pubmed ID: 34289384
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Immunity Aug, 2021 | Pubmed ID: 34331873
Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.
Nature Sep, 2021 | Pubmed ID: 34345019
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
Nature communications Aug, 2021 | Pubmed ID: 34373458
Autoantibodies neutralizing type I IFNs are present in 4% of uninfected individuals over 70 years old and account for 20% of COVID-19 deaths.
Science immunology Aug, 2021 | Pubmed ID: 34413139
High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape.
Nature Dec, 2021 | Pubmed ID: 34544114
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.
Nature Dec, 2021 | Pubmed ID: 34619745
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence.
The Journal of experimental medicine Dec, 2021 | Pubmed ID: 34636876
Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope.
NPJ vaccines Oct, 2021 | Pubmed ID: 34697307
Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env.
Science translational medicine Nov, 2021 | Pubmed ID: 34818054
Plasma neutralization properties of the SARS-CoV-2 Omicron variant.
medRxiv : the preprint server for health sciences Dec, 2021 | Pubmed ID: 34931199
Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2022 | Pubmed ID: 35042816
Germinal Centers.
Annual review of immunology Apr, 2022 | Pubmed ID: 35113731
Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins.
bioRxiv : the preprint server for biology Feb, 2022 | Pubmed ID: 35132412
Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.
Nature communications Feb, 2022 | Pubmed ID: 35136084
The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection-study protocol for a two-stage randomised phase II trial.
Trials Apr, 2022 | Pubmed ID: 35382844
Prolonged viral suppression with anti-HIV-1 antibody therapy.
Nature Jun, 2022 | Pubmed ID: 35418681
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost.
Nature Jul, 2022 | Pubmed ID: 35447027
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.
Immunity Jun, 2022 | Pubmed ID: 35447092
Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial.
The Lancet. Microbe Mar, 2022 | Pubmed ID: 35544074
Combination anti-HIV antibodies provide sustained virological suppression.
Nature Jun, 2022 | Pubmed ID: 35650437
Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans.
The Journal of experimental medicine Aug, 2022 | Pubmed ID: 35776090
Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants.
The Journal of experimental medicine Sep, 2022 | Pubmed ID: 35796685
Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection.
Open forum infectious diseases Jul, 2022 | Pubmed ID: 35818364
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.
Science advances Aug, 2022 | Pubmed ID: 35960796
Antibody feedback regulation of memory B cell development in SARS-CoV-2 mRNA vaccination.
medRxiv : the preprint server for health sciences Aug, 2022 | Pubmed ID: 35982682
Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.
The Journal of experimental medicine Oct, 2022 | Pubmed ID: 36006380
Two complementary features of humoral immune memory confer protection against the same or variant antigens.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2022 | Pubmed ID: 36006981
Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape.
bioRxiv : the preprint server for biology Aug, 2022 | Pubmed ID: 36032981
Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain.
bioRxiv : the preprint server for biology Aug, 2022 | Pubmed ID: 36052368
Distinct gene expression by expanded clones of quiescent memory CD4 T cells harboring intact latent HIV-1 proviruses.
Cell reports Sep, 2022 | Pubmed ID: 36070690
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans.
The Journal of experimental medicine Dec, 2022 | Pubmed ID: 36149398
HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design.
Nature communications Oct, 2022 | Pubmed ID: 36253376
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.
Nature medicine Nov, 2022 | Pubmed ID: 36253609
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8 T cell immunity.
Nature communications Oct, 2022 | Pubmed ID: 36309514
HIV-1 Vpu restricts Fc-mediated effector functions in vivo.
Cell reports Nov, 2022 | Pubmed ID: 36351384
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
Nature Jan, 2023 | Pubmed ID: 36473496
Continuous germinal center invasion contributes to the diversity of the immune response.
Cell Jan, 2023 | Pubmed ID: 36565698
Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape.
Nature communications Jan, 2023 | Pubmed ID: 36653360
Harald Hartweger1,
Rajeev Gautam2,
Yoshiaki Nishimura2,
Fabian Schmidt3,5,
Kai-Hui Yao1,
Amelia Escolano1,6,
Mila Jankovic1,
Malcolm A. Martin2,
Michel C. Nussenzweig1,4
1Laboratory of Molecular Immunology, The Rockefeller University,
2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,
3Laboratory of Retrovirology, The Rockefeller University,
4Howard Hughes Medical Institute, The Rockefeller University,
5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST),
6Vaccine and Immunotherapy Center, Wistar Institute
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