Laboratory of Molecular Immunology
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The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin.
The Journal of experimental medicine Apr, 2000 | Pubmed ID: 10748230
OcaB regulates transitional B cell selection.
International immunology Sep, 2003 | Pubmed ID: 12917262
RAGs and regulation of autoantibodies.
Annual review of immunology , 2004 | Pubmed ID: 15032586
AID is required for c-myc/IgH chromosome translocations in vivo.
Cell Aug, 2004 | Pubmed ID: 15315756
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Nature Mar, 2006 | Pubmed ID: 16400328
Antigen receptor diversification and chromosome translocations.
Nature immunology Aug, 2007 | Pubmed ID: 17641661
A role for AID in chromosome translocations between c-myc and the IgH variable region.
The Journal of experimental medicine Sep, 2007 | Pubmed ID: 17724134
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.
Immunity May, 2008 | Pubmed ID: 18455451
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Molecular cell May, 2009 | Pubmed ID: 19450527
Role of the translocation partner in protection against AID-dependent chromosomal translocations.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2010 | Pubmed ID: 19966290
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133803
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
The Journal of experimental medicine Feb, 2010 | Pubmed ID: 20142431
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.
The Journal of experimental medicine May, 2010 | Pubmed ID: 20385748
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Science (New York, N.Y.) Aug, 2010 | Pubmed ID: 20671152
Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness.
The Journal of experimental medicine Aug, 2010 | Pubmed ID: 20679402
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.
Cell Oct, 2010 | Pubmed ID: 20887897
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Cell Sep, 2011 | Pubmed ID: 21962510
Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements.
Journal of immunological methods Jan, 2012 | Pubmed ID: 22033343
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).
Proceedings of the National Academy of Sciences of the United States of America Feb, 2012 | Pubmed ID: 22308491
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Nature Feb, 2012 | Pubmed ID: 22314321
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science (New York, N.Y.) Feb, 2013 | Pubmed ID: 23306439
T follicular helper cell dynamics in germinal centers.
Science (New York, N.Y.) Aug, 2013 | Pubmed ID: 23887872
Identification of chromosomal translocation hotspots via scan statistics.
Bioinformatics (Oxford, England) Sep, 2014 | Pubmed ID: 24860160
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Cell Dec, 2014 | Pubmed ID: 25483777
Epigenetic targeting of activation-induced cytidine deaminase.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25512519
HIV-1 integration landscape during latent and active infection.
Cell Jan, 2015 | Pubmed ID: 25635456
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.
Cell Aug, 2015 | Pubmed ID: 26276629
Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2016 | Pubmed ID: 27872306
The cell cycle restricts activation-induced cytidine deaminase activity to early G1.
The Journal of experimental medicine Jan, 2017 | Pubmed ID: 27998928
Clonal CD4 T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation.
Nature medicine May, 2018 | Pubmed ID: 29686423
Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117.
The Journal of experimental medicine Sep, 2018 | Pubmed ID: 30072495
Relationship between intact HIV-1 proviruses in circulating CD4 T cells and rebound viruses emerging during treatment interruption.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2018 | Pubmed ID: 30420517
HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells.
The Journal of experimental medicine Jun, 2019 | Pubmed ID: 30975893
Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir.
The Journal of experimental medicine Oct, 2019 | Pubmed ID: 31350309
Isolation of single HIV-1 Envelope specific B cells and antibody cloning from immunized rhesus macaques.
Journal of immunological methods Mar, 2020 | Pubmed ID: 31866284
Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.
Nature medicine Feb, 2020 | Pubmed ID: 32015556
Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir.
The Journal of experimental medicine Jul, 2020 | Pubmed ID: 32311008
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations.
Cell host & microbe Aug, 2020 | Pubmed ID: 32504577
Evolution of antibody immunity to SARS-CoV-2.
Nature Mar, 2021 | Pubmed ID: 33461210
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection.
Nature Jul, 2021 | Pubmed ID: 34126625
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.
Nature Dec, 2021 | Pubmed ID: 34619745
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence.
The Journal of experimental medicine Dec, 2021 | Pubmed ID: 34636876
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost.
Nature Jul, 2022 | Pubmed ID: 35447027
Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans.
The Journal of experimental medicine Aug, 2022 | Pubmed ID: 35776090
Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.
The Journal of experimental medicine Oct, 2022 | Pubmed ID: 36006380
Distinct gene expression by expanded clones of quiescent memory CD4 T cells harboring intact latent HIV-1 proviruses.
Cell reports Sep, 2022 | Pubmed ID: 36070690
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans.
The Journal of experimental medicine Dec, 2022 | Pubmed ID: 36149398
Harald Hartweger1,
Rajeev Gautam2,
Yoshiaki Nishimura2,
Fabian Schmidt3,5,
Kai-Hui Yao1,
Amelia Escolano1,6,
Mila Jankovic1,
Malcolm A. Martin2,
Michel C. Nussenzweig1,4
1Laboratory of Molecular Immunology, The Rockefeller University,
2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,
3Laboratory of Retrovirology, The Rockefeller University,
4Howard Hughes Medical Institute, The Rockefeller University,
5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST),
6Vaccine and Immunotherapy Center, Wistar Institute
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