Charalabos Pothoulakis

Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways.

Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins.

Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A.

Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice.

Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells.

Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation.

Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum.

Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases.

Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction.

Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways.

Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter.

Leptin mediates Clostridium difficile toxin A-induced enteritis in mice.

Development of microbial-human enterocyte interaction: cholera toxin.

Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.

A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus.

Rho GTPases as therapeutic targets for the treatment of inflammatory diseases.

MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells.

Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.

Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells.

Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes.

Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters.

Bacterial infections: small intestine and colon.

Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia.

Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha.

Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea.

Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.

Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes.

Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation.

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.

Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.

Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression.

Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.

Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells.

Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells.

Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells.

The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats.

Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis.

Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.

Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation.

Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses.

Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.

Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines.

Immunomodulatory properties of substance P: the gastrointestinal system as a model.

Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells.

Substance P mediates antiapoptotic responses in human colonocytes by Akt activation.

Role of neuropeptides in inflammatory bowel disease.

Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.

Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha.

Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor.

Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.

Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand.

Obesity, innate immunity and gut inflammation.

Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters.

Substance P as a novel anti-obesity target.

Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.

Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis.

gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.

Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer.

Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis.

Melanin-concentrating hormone as a mediator of intestinal inflammation.

Neuropeptides, mesenteric fat, and intestinal inflammation.

Substance P, obesity, and gut inflammation.

Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress.

Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.

Principles and clinical implications of the brain-gut-enteric microbiota axis.

Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis.

Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin.

Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice.

Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes.

Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice.

Serotonin has a critical role in the pathogenesis of experimental colitis.

The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition.

Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.

TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5.

The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8.

Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation.

Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis.

TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells.

Substance P modulates colitis-associated fibrosis.

Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells.

Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.

Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents.

Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action.

Neuropeptide - adipose tissue communication and intestinal pathophysiology.

The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer.

Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice.

Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.

The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity.

Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins.

The effects of acute and chronic psychological stress on bladder function in a rodent model.

Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells.

Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.

Serum and colonic mucosal immune markers in irritable bowel syndrome.

Clostridial toxins: sensing a target in a hostile gut environment.

Adipose tissue and inflammatory bowel disease pathogenesis.

Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.

Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders.

Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice.

The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice.

Antimicrobial Peptides and Colitis.