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Na Homolce Hospital

2 ARTICLES PUBLISHED IN JoVE

Medicine

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Pavel Hála^1,2, Mikuláš Mlček¹, Petr Ošťádal^1,2, David Janák^1,3, Michaela Popková¹, Tomáš Bouček¹, Stanislav Lacko¹, Jaroslav Kudlička¹, Petr Neužil^1,2, Otomar Kittnar¹

¹Department of Physiology, First Faculty of Medicine, Charles University, ²Department of Cardiology, Na Homolce Hospital, ³Department of Cardiovascular Surgery, Second Faculty of Medicine, Charles University

Here, we present a protocol to produce tachycardia-induced cardiomyopathy in swine. This model represents a potent way to study the hemodynamics of progressive chronic heart failure and the effects of applied treatment.

Medicine

Translational Rabbit Model of Chronic Cardiac Pacing

Vinisha Somaya¹, Michaela Popkova¹, David Janak^2,3, Ilona Princova^2,4, Mikulas Mlcek², Jan Petru¹, Petr Neuzil¹, Otomar Kittnar², Pavel Hala¹

¹Department of Cardiology, Na Homolce Hospital, ²Department of Physiology, First Faculty of Medicine, Charles University, ³Department of Cardiovascular Surgery, Second Faculty of Medicine, Charles University, ⁴Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University

We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies.