Na Homolce Hospital
2 ARTICLES PUBLISHED IN JoVE
Medicine
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Pavel Hála 1,2, Mikuláš Mlček 1, Petr Ošťádal 1,2, David Janák 1,3, Michaela Popková 1, Tomáš Bouček 1, Stanislav Lacko 1, Jaroslav Kudlička 1, Petr Neužil 1,2, Otomar Kittnar 1
1Department of Physiology, First Faculty of Medicine, Charles University, 2Department of Cardiology, Na Homolce Hospital, 3Department of Cardiovascular Surgery, Second Faculty of Medicine, Charles University
Here, we present a protocol to produce tachycardia-induced cardiomyopathy in swine. This model represents a potent way to study the hemodynamics of progressive chronic heart failure and the effects of applied treatment.
Medicine
Translational Rabbit Model of Chronic Cardiac Pacing
Vinisha Somaya 1, Michaela Popkova 1, David Janak 2,3, Ilona Princova 2,4, Mikulas Mlcek 2, Jan Petru 1, Petr Neuzil 1, Otomar Kittnar 2, Pavel Hala 1
1Department of Cardiology, Na Homolce Hospital, 2Department of Physiology, First Faculty of Medicine, Charles University, 3Department of Cardiovascular Surgery, Second Faculty of Medicine, Charles University, 4Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University
We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies.
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