The overall goal of the following procedure is to demonstrate the labeling of a ligand with the radionuclide fluorine-18, or F-18, using silicon fluoride acceptor compounds, hereafter referred to as SiFAs. Labeling a ligand with F-18 and injecting
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The synthesis of fluorine-18 (18F) labeled radiopharmaceuticals for positron emission tomography typically requires months of experience. When incorporated into a radiotracer, the silicon-fluoride acceptor (SiFA) motif enables a simple 18F-labeling protocol that is independent of costly equipment and preparatory training, while reducing precursor quantity needed and utilizing milder reaction conditions.