¹⁸F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

7.3K Views

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09:57 min

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January 11th, 2020

DOI :

10.3791/60623-v

January 11th, 2020

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David Connolly*¹, Justin J. Bailey*¹, Harun Ilhan²^,³, Peter Bartenstein²^,³, Carmen Wängler⁴, Björn Wängler⁵, Melinda Wuest¹, Frank Wuest¹, Ralf Schirrmacher¹

¹Department of Oncology, University of Alberta, ²Department of Nuclear Medicine, University Hospital of Munich, ³ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, ⁴Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, ⁵Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University

Summary

Explore More Videos

F 18 Labeling

Radiotracers

Silicon Fluoride Acceptor

SiFA

Positron Emission Tomography

Derivatized Phenyl Moiety

Hydrolytic Stability

In vivo Applications

Chemical Identity

Non canonical Labeling Technique

Radiation Detection

Chapters in this video

0:00

Title

4:27

Azeotropic Drying of F-18 Anion

6:28

One Step SiFA-Ligand Labelling

8:19

Results

9:07

Conclusion

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18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

¹⁸F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography