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Pharmacology

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17.2 : Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.

Seizures are typically classified into two main categories: focal and generalized seizures.

Focal Seizures

Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

  1. Focal aware seizures: In these seizures, the person remains conscious throughout the event. They are fully aware of their surroundings and can recall the seizure afterward.
  2. Focal impaired awareness seizures: In contrast, consciousness is lost during a focal impaired awareness seizure. The individual may appear dazed or confused and might not remember the seizure.

Generalized Seizures

Generalized seizures engage both hemispheres of the brain right from the onset. These seizures are further classified into several types:

  1. Generalized absence seizures are marked by brief lapses in consciousness, often as staring spells.
  2. Tonic-clonic seizures involve a loss of consciousness and violent muscle contractions.
  3. Myoclonic seizures cause quick and involuntary muscle jerks.
  4. Clonic seizures manifest as repetitive jerking movements.
  5. Tonic seizures lead to stiffening of the muscles.
  6. Atonic seizures lead to a sudden loss of muscle control, and the person can collapse.

There are also several significant epilepsy syndromes, including infantile spasms, Lennox-Gastaut syndrome, juvenile myoclonic epilepsy, and Dravet syndrome. Each of these syndromes has unique characteristics and treatment approaches. Understanding the different types of seizures and epilepsy syndromes is crucial for appropriate diagnosis and treatment.

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