May 13th, 2010
•Aptamers are short ribo-/deoxyribo-oligonucleotides selected by in-vitro evolution methods based on affinity for a specific target. Aptamers are molecular recognition tools with versatile therapeutic, diagnostic, and research applications. We demonstrate methods for selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease.
Tags
Related Videos
Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction
Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain
In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved