High-Quality Seizure-Like Activity from Acute Brain Slices Using a Complementary Metal-Oxide-Semiconductor High-Density Microelectrode Array System

1.9K Views

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06:28 min

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September 27th, 2024

DOI :

10.3791/67065-v

September 27th, 2024

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Melissa L. Blotter*¹^,², Isaac W. Stubbs*¹^,², Jacob H. Norby*¹^,², Maxwell Holmes¹^,², Ben Kearsley³, Alexis Given¹, Kutter Hine¹^,⁴, Micah R. Shepherd⁵, R. Ryley Parrish¹^,²

¹Department of Cell Biology and Physiology, Brigham Young University, ²Neuroscience Center, Brigham Young University, ³Department of Statistics, Brigham Young University, ⁴Department of Biology, Brigham Young University, ⁵Department of Physics and Astronomy, Brigham Young University

Transcript

Summary

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Seizure like Activity

Acute Brain Slices

CMOS HD MEA System

High density Microelectrode Array

Electrophysiological Data

Status Epilepticus

Local Field Potentials

Neurophysiological Activity

Neuronal Unit Activity

Experimental Protocol

Treatment Methods

Brain Slice Recording

Electrical Noise

Chapters in this video

0:00

Introduction

1:00

Equipment Preparation for CMOS‐HD‐MEA Experimentation

2:23

Chip Preparation and Placement of Brain Slice to Record High‐Quality Seizure‐Like Activity Using CMOS‐HD‐MEA System

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