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The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

DOI :

10.3791/3039-v

July 25th, 2011

July 25th, 2011

19,271 Views

1Department of Pharmacology and Physiology, University of Rochester, 2Department of Neurology, University of Alabama at Birmingham, 3Departments of Anesthesiology, Pharmacology and Physiology, University of Rochester

Middle cerebral artery (MCA) ligation is a technique to study focal cerebral ischemia in animal models. In this method, the middle cerebral artery is exposed by craniotomy and ligated by cauterization. This method gives highly reproducible infarct volumes and increased post-operative survival rates compared to other methods available.

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Permanent MCA Ligation

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