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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

DOI :

10.3791/3122-v

10:09 min

January 3rd, 2012

January 3rd, 2012

18,556 Views

1Centre for Immunity, Infection and Evolution, University of Edinburgh

An in vitro model for cerebral malaria sequestration is described1. Plasmodium falciparum infected red blood cells are selected for binding to immortalized human brain microvascular endothelial cells. The selected parasites show a distinct phenotype. The selection process can be applied using various P. falciparum strains and endothelial cell lines.

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Plasmodium Falciparum

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