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Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

DOI :

10.3791/3905-v

June 5th, 2012

June 5th, 2012

13,624 Views

1Institute of Immunology, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania , 2Pathobiology, School of Veterinary Medicine, University of Pennsylvania

Schistosoma mansoni eggs are potent stimulators of the T helper type 2 (Th2) immune response, characteristic of parasite infection, asthma and allergic inflammation. This protocol utilizes S. mansoni egg injection to generate a CD4 Th2 cytokine-induced inflammatory response in the lung, characterized by lung granuloma formation around the egg, eosinophilia and macrophage alternative activation.

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Schistosoma Mansoni

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