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The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System Video (Video) | JoVE

DOI :

10.3791/3956-v

11:27 min

April 25th, 2012

April 25th, 2012

15,054 Views

1Department of Radiology, Brain Imaging Center, Academic Medical Center Amsterdam, 2Biological Imaging Centre, MRC Clinical Sciences Centre, Imperial College London

The goal of this technique is to assess serotonin (5-HT) neurotransmitter function in the live and free-breathing animal with pharmacological magnetic resonance imaging (phMRI) and an intravenous challenge with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

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Pharmacological challenge FMRI

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