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2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

DOI :

10.3791/50173-v

June 22nd, 2013

June 22nd, 2013

19,592 Views

1Department of Emergency Medicine, Wayne State University School of Medicine, 2Cardiovascular Research Institute, Wayne State University School of Medicine, 3Department of Physiology, Wayne State University School of Medicine

Bilateral carotid occlusion coupled with systemic hypotension produces global brain ischemia in the rat, resulting in damage to the hippocampus with reproducible severity. Animal subjects are impaired with predictable patterns of brain damage, they recover expediently, and mortality rates are comparatively low.

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