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A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

DOI :

10.3791/3896-v

July 17th, 2012

July 17th, 2012

28,008 Views

1Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany, 2Institute of Physiology, University of Bonn, Germany

Surgical trauma induces an inflammatory response. Cytokines and endogenous ligands are known to modulate myocardial infarct size following ischemia and reperfusion. We present a modified closed-chest model of murine ischemia and reperfusion using hanging weights to minimize effects of thoracotomy.

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Murine Closed chest Model

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