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Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

DOI :

10.3791/50019-v

November 30th, 2012

November 30th, 2012

19,003 Views

1Department of Neurological Surgery, Vanderbilt University School of Medicine

Blood-brain barrier disruption aids the delivery of certain drugs to the brain. Mannitol delivered intra-arterially shrinks cells surrounding blood vessels in order to physically disrupt the barrier.

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