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Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

DOI :

10.3791/51134-v

11:40 min

April 1st, 2014

April 1st, 2014

14,356 Views

1INSERM U970, Paris Cardiovascular Research Centre, 2Faculté de Médecine Paris Descartes, Université Paris Descartes

Neisseria meningitidis is a human specific pathogen that infects blood vessels. In this protocol human microvessels are introduced into a mouse by grafting human skin onto immunocompromised mice. Bacteria adhere extensively to the human vessels, leading to vascular damage and development of the purpuric rash typically observed in human cases.

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Humanized Mouse Model

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