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Using Luciferase to Image Bacterial Infections in Mice Video (Video) | JoVE

DOI :

10.3791/2547-v

February 18th, 2011

February 18th, 2011

19,816 Views

1Microbial & Molecular Pathogenesis, Texas A&M Health Science Center

Methods for bioluminescence imaging of bacterial infections in living animals are decribed. Pathogens are modified to express luciferase allowing optical whole body imaging of infections in live animals. Animal models can be infected with luciferase expressing pathogens and the resulting course of disease visualized in real-time by bioluminescence imaging.

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