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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

DOI :

10.3791/51712-v

July 22nd, 2014

July 22nd, 2014

8,335 Views

1Department of Biochemistry, McGill University, 2Institute of Parasitology, McGill University, 3McGill Centre for Bioinformatics, McGill University

A highly sensitive ribozyme-based assay, applicable to high-throughput screening of chemicals targeting the unique process of RNA editing in trypanosomatid pathogens, is described in this paper. Inhibitors can be used as tools for hypothesis-driven analysis of the RNA editing process and ultimately as therapeutics.

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RNA Catalyst

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