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Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

DOI :

10.3791/52556-v

March 12th, 2015

March 12th, 2015

10,896 Views

1Department of Microbiology and Immunology, New York Medical College

Forward genetics is a powerful approach to identify genes in intracellular pathogens important for resistance to cell autonomous immunity. The current approach uses innate immune cells, specifically macrophages, to identify novel Toxoplasma gondii genes important for immune evasion.

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Genetics Screens

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