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Paw-Dragging: a Novel, Sensitive Analysis of the Mouse Cylinder Test

DOI :

10.3791/52701-v

April 29th, 2015

April 29th, 2015

22,031 Views

1BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, 2Neurosciences, Faculty of Medicine, McGill University

Classical forelimb asymmetry analysis of the cylinder test is routinely used to assess behavioural deficits in rats following brain injury or stroke; however, it fails to detect consistent deficits in mice. This study demonstrates that quantifying paw-dragging behaviour is a more sensitive analysis of brain injury in mice.

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