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Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts

DOI :

10.3791/52908-v

July 27th, 2015

July 27th, 2015

22,127 Views

1Department of Medicine/Cardiology, Gazes Cardiac Research Institute, Medical University of South Carolina, 2Ralph H. Johnson VA Medical Center, Medical University of South Carolina

The isolated rat heart is an enduring model for ischemia reperfusion injury. Here, we describe the process of harvesting the beating heart from a rat via in situ aortic cannulation, Langendorff perfusion of the heart, simulated ischemia-reperfusion injury, and infarct staining to confirm the extent of ischemic insult.

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Induction

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