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Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

DOI :

10.3791/53310-v

March 30th, 2016

March 30th, 2016

12,664 Views

1Department of Physiology, Northwestern University

The preparation presented here for whisker-signaled eyeblink conditioning in head-fixed mice precisely stimulates specific whiskers while allowing mice to ambulate on a cylindrical treadmill. A whisker stimulation conditioned stimulus (CS) paired with a periorbital shock unconditioned stimulus (US) results in reliable associative learning on this apparatus.

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