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Modeling Chemotherapy Resistant Leukemia In Vitro

DOI :

10.3791/53645-v

February 9th, 2016

February 9th, 2016

8,851 Views

1Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program of the Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, 2Department of Neurobiology and Anatomy, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, 3Department of Microbiology, Immunology and Cell Biology, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine

The current report summarizes a protocol that can be utilized to model the influence of the bone marrow microenvironment niche on leukemic cells with emphasis placed on enrichment of the most chemoresistant subpopulation.

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Keywords Modeling Chemotherapy Resistant Leukemia Acute Lymphoblastic Leukemia ALL Bone Marrow Microenvironment Leukemic Cell Culture Adherent Cell Monolayer Phase Bright And Phase Dim Leukemic Cells G10 Bead Columns Cell Separation

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