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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

DOI :

10.3791/53785-v

April 24th, 2016

April 24th, 2016

11,092 Views

1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 2Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, DHHS

Salivary gland hypofunction, a major adverse effect of head and neck radiotherapy diminishes a patient's quality of life. The demonstration of efficacy of new therapies in animal models is a prerequisite before clinical transition. This protocol describes retroductal administration and local irradiation of rat submandibular glands.

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Retroductal Submandibular Gland Instillation

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