Results: Touch Dome Cells and Merkel Cells Require Innervation
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Conclusion
Transcript
The overall goal of this procedure is to examine the influence of nerves on normal and pathological skin. This method can be used to answer key questions in normal skin biology, such as whether cutaneous nerves affect homeostasis and disease. The
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This article includes detailed protocols for genetic labeling of mouse skin, surgical denervation, skin biopsy and visualizing labeled epithelia by whole-mount β-galactosidase staining. These methods can be used to test the requirement for nerves in mouse models of normal and pathological skin.