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Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

DOI :

10.3791/54396-v

September 29th, 2016

September 29th, 2016

6,810 Views

1Department of Organic Chemistry, Weizmann Institute of Science

We present guidelines for developing synthetic 'chemical transducers' that can induce communication between naturally unrelated proteins. In addition, detailed protocols are presented for synthesizing and testing a specific 'transducer' that enables a growth factor to activate a detoxifying enzyme and consequently, to regulate the cleavage of an anticancer prodrug.

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Signaling Proteins

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