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JoVE Journal

Bioengineering

This content is Open Access.

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

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12:07 min

April 16th, 2018

April 16th, 2018

13,091 Views

0:04

Title

0:49

Fabrication of Hydrazone-crosslinked Bulk Poly(Oligoethylene Glycol Methacrylate)(POEGMA) or Poly(N-Isopropylacrylamide) (PNIPAM) Hydrogels

2:41

Fabrication of Hydrazone-crosslinked PNIPAM Gel Microparticles via Reactive Microfluidics

6:18

Thermally-driven Reactive Self-assembly of Hydrazone-crosslinked PNIPAM Nanogels

7:34

Fabrication of Hydrazone- crosslinked POEGMA Nanofibers via Reactive Electrospinning

9:28

Results: Bulk, Microscale, and Nanoscale Thermoresponsive Hydrogels

11:17

Conclusion

Transcript

Protocols are described for the fabrication of degradable thermoresponsive hydrogels based on hydrazone cross-linking of polymeric oligomers on the bulk scale, microscale, and nanoscale, the latter for preparation of both gel nanoparticles and nanofibers.

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