Results: Representative Post-injury Histopathological and Albumin Leakage Analyses
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Conclusion
Transcript
The overall goal of this murine gastric acid aspiration model is to produce a sterile acute lung injury in a mouse that has close fidelity to the pathogenesis of acid pneumonitis observed in humans. This method can help answer key questions in the
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This protocol induces acute lung injury in a mouse that has close fidelity to the pathogenesis of acid pneumonitis observed in humans. We generate a maximal acute nonlethal low pH lung injury and account for differences in rodent-human anatomic respiratory structure using an open tracheostomy coupled with circumferential pressure release.